Cdc6基因在肺癌性胸腔积液中的表达及临床意义  

EXPRESSION AND CLINICAL SIGNIFICANCE OF CDC6 GENE IN LUNG CANCER PLEURAL EFFUSION

作　　者：董量 彭玉梅[1] 董桂兰 刘丽丽[1] 刘卫东[1] 胡万宁[1] 谷雪 李欢[1] DONG Liang;PENG Yumei;DONG Guilan;LIU Lili;LIU Weidong;HU Wanning;GU Xue;LI Huan(Tangshan People’s Hospital,Tangshan 063000,China)

机构地区：[1]河北省唐山市人民医院,063000 [2]唐山市肿瘤放射治疗学重点实验室

出　　处：《中国煤炭工业医学杂志》2021年第1期1-4,共4页Chinese Journal of Coal Industry Medicine

基　　金：2018年度河北省医学科学研究重点课题(编号:20181243)。

摘　　要：目的探讨Cdc6基因在肺癌性胸腔积液中的表达及其临床意义。方法以Cdc6 mRNA为分子标志物,应用实时定量PCR技术,检测恶性胸腔积液中Cdc6基因mRNA的表达并同时检测出现脑转移肿瘤标本中Cdc6基因mRNA的表达情况。结果Cdc6在肺癌胸腔积液中均有表达,且肺癌患者中的表达量均值与肺癌不同分期(ⅢB和Ⅳ期)差异有统计学意义(均P<0.05),系统放化疗后患者Cdc6在肺癌胸腔积液中的表达水平与治疗前差异有统计学意义(P<0.05),在发生脑转移肿瘤组织中Cdc6基因表达水平与肺癌胸腔积液中的表达水平呈正相关(P<0.05)。结论Cdc6在胸腔积液中的表达量与肺癌恶性程度及治疗效果相关,与肺癌是否发生脑转移有关,对临床有指导意义。Objective To investigate the expression and clinical significance of Cdc6 in malignant pleural effusion.Methods Using Cdc6 mRNA as molecular markers,the expression of Cdc6 mRNA in malignant pleural effusion was detected by real-time quantitative PCR,and the expression of Cdc6 mRNA in brain metastatic tumor specimens was also detected.Results Cdc6 have expression in lung cancer,pleural effusion,and the average amount of expression in the patients with lung cancer and lung cancer of different stages(ⅢB andⅣperiod)had significant difference(P<0.05),radiation and chemotherapy patients after treatment in the system Cdc6 expression level in lung cancer,pleural effusion and significant difference before treatment(P<0.05),Cdc6 gene expression level in brain metastases tumor expression level of pleural effusion is related with lung cancer(P<0.05).Conclusion The expression level of Cdc6 in pleural effusion is related to the degree of malignancy and treatment effect of lung cancer,and is related to the occurrence of brain metastasis of lung cancer,which has guiding significance for clinical practice.

关 键 词：Cdc6基因 胸腔积液 肺癌 脑转移 

分 类 号：R734.2[医药卫生—肿瘤]