ASPH、AFP水平与肝细胞癌术后复发的关系研究  

RELATIONSHIP BETWEEN ASPH,AFP LEVELS AND POSTOPERATIVE RECURRENCE OF HEPATOCELLULAR CARCINOMA

作　　者：张群[1] 汤山松 杨霞[1] ZHANG Qun;TANG Shansong;YANG Xia(Department of Oncology,Ziyang People’s Hospital,Ziyang 641300,China)

机构地区：[1]四川省资阳市人民医院肿瘤科,641300

出　　处：《中国煤炭工业医学杂志》2021年第1期72-76,共5页Chinese Journal of Coal Industry Medicine

基　　金：四川省卫生厅科研课题(编号:20170227)。

摘　　要：目的探讨血清天冬氨酸-天冬酰胺β羟化酶(ASPH)、甲胎蛋白(AFP)与肝细胞癌手术切除后复发的关系。方法选取该院手术治疗的134例原发性肝细胞癌患者作为研究对象,对患者进行术后随访,随访期限为2年,以患者出现术后复发作为观察终点,其中75例患者出现复发(复发组)、52例患者未出现复发(非复发组)、失访7例;比较二组患者血清ASPH、AFP水平及临床病理学特征;采用二元Logistic回归分析法探讨血清ASPH、AFP水平与肝细胞癌手术切除后复发的关系。结果复发组患者的血清ASPH、AFP水平均高于非复发组患者,差异均有统计学意义(均P<0.05);复发组与非复发组患者的年龄、性别、肿瘤病灶大小、乙肝病史、病理学分化程度、术前血清白蛋白(ALB)水平差异均无统计学意义(均P>0.05);复发组患者的TNM分期、门脉癌栓、微血管浸润程度与非复发组患者比较,差异均有统计学意义(均P<0.05);经Logistic回归分析,TNM分期增高、术前合并门脉癌栓、血清ASPH水平增高是肝细胞癌手术切除后复发的独立危险因素(均P<0.05)。结论肝细胞癌手术切除后复发的危险因素很多,血清ASPH水平增高是危险因素之一。Objective To investigate the relationship between serum aspartate-asparagine beta hydroxylase(ASPH),alpha-fetoprotein(AFP)and recurrence after hepatectomy for hepatocellular carcinoma.Methods One hundred and thirty four patients with primary hepatocellular carcinoma who underwent surgery in Ziyang People’s Hospital were selected as the study subjects.The patients were followed up for 2 years.The patients had recurrence as the end point.Among them,75 patients had recurrence(recurrence Group),52 patients had no recurrence(non-recurrence group),7 patients were lost to follow-up.Serum ASPH,AFP levels and clinicopathological features were compared between the two groups.Serum ASPH,AFP levels and liver were explored by binary logistic regression analysis.The relationship between recurrence after surgical resection of cell cancer.Results The serum levels of ASPH and AFP in the relapse group were significantly higher than those in the non-recurrent group(P<0.05).The age,sex,tumor size,history of hepatitis B,and pathological differentiation of the relapsed and non-recurrent groups.There was no significant difference in the degree of preoperative serum ALB levels(P>0.05).The TNM stage,portal vein tumor thrombus and microvascular infiltration in the recurrent group were significantly different from those in the non-recurrent group(P<0.05).Logistic regression analysis showed that increased TNM stage,preoperative portal vein tumor thrombus,and elevated serum ASPH levels were independent risk factors for recurrence of hepatocellular carcinoma after surgical resection(P<0.05).Conclusion There are many risk factors for recurrence of hepatocellular carcinoma after surgical resection,and elevated serum ASPH levels are one of the risk factors.

关 键 词：天冬氨酸-天冬酰胺β羟化酶 甲胎蛋白 肝细胞癌 复发 

分 类 号：R735.7[医药卫生—肿瘤]