Cost-effectiveness analysis of malaria rapid diagnostic test in the elimination setting  

作　　者：Yan-Qiu Du Xiao-Xiao Ling Jia-Jie Jin Hua-Yun Zhou Si Zhu Guo-Ding Zhu Wei Wang Jun Cao Jia-Yan Huang 

机构地区：[1]Key Lab of Health Technology Assessment,National Health Commission,School of Public Health,Fudan University,Shanghai 200433,China [2]不详 [3]National Health Commission Key Laboratory of Parasitic Disease Control and Prevention,Jiangsu Provincial Key Laboratory of Parasite and Vector Control Technology,Jiangsu Institute of Parasitic Diseases,Wuxi 214064,China

出　　处：《Infectious Diseases of Poverty》2020年第5期122-122,共1页贫困所致传染病（英文）

摘　　要：Background:As more and more countries approaching the goal of malaria elimination,malaria rapid diagnostic tests(RDT)was recomendated to be a diagnostic strategy to achieve and maintain the statute of malaria free,as it’s less requirments on equipment and experitise than microscopic examination.But there are very few economic evaluations to confirm whether RDT was cost-effective in the setting of malaria elimination.This research aimed to offer evidence for helping decision making on malaria diagnosis strategy.Methods:A cost-effectiveness analysis was conducted to compare RDT with microscopy examination for malaria diagnosis,by using a decision tree model.There were three strategies of malaria diagnostic testing evaluated in the model,1)microscopy,2)RDT,3)RDT followed by microscopy.The effect indicator was defined as the number of malaria cases treated appropriately.Based on the joint perspective of health sector and patient,costs data were collected from hospital information systems,key informant interviews,and patient surveys.Data collection was conducted in Jiangsu from September 2018 to January 2019.Epidemiological data were obtained from local malaria surveillance reports.A hypothetical cohort of 300000 febrile patients were simulated to calculate the total cost and effect of each strategy.One-way,two-way,and probabilistic sensitivity analysis were performed to test the robustness of the result.Results:The results showed that RDT strategy was the most effective(245 cases)but also the most costly(United States Dollar[USD]4.47 million)compared to using microscopy alone(238 cases,USD 3.63 million),and RDT followed by microscopy(221 cases,USD 2.75 million).There was no strategy dominated.One-way sensitivity analysis reflected that the result was sensitive to the change in labor cost and two-way sensitivity analysis indicated that the result was not sensitive to the proportion of falciparum malaria.The result of Monte Carlo simulation showed that RDT strategy had higher effects and higher cost than other strate

关 键 词：Cost-effectiveness analysis Monte Carlo simulation Malaria elimination Rapid diagnostic test MICROSCOPY 

分 类 号：R531.3[医药卫生—内科学]