Müller细胞与视网膜神经再生研究进展  

Research progress of Müller cells and retinal nerve regeneration

作　　者：贾茜钰 蓝诗翰 单亭 叶河江[2] 陈婕[2] Xi-Yu Jia;Shi-Han Lan;Ting Shan;He-Jiang Ye;Jie Chen(Chengdu University of Traditional Chinese Medicine,Chengdu 610072,Sichuan Province,China;Department of Ophthalmology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China)

机构地区：[1]成都中医药大学,中国四川省成都市610072 [2]成都中医药大学附属医院眼科,中国四川省成都市610075

出　　处：《国际眼科杂志》2021年第2期240-243,共4页International Eye Science

基　　金：国家自然科学基金面上项目(No.81774371);成都中医药大学“杏林学者”基金项目(No.YXRC2019010);成都中医药大学附属医院科技发展基金项目(No.19ZL02)。

摘　　要：视网膜退行性疾病是以视网膜神经元凋亡为主要病理过程的一类致盲性眼病,视网膜神经元受损后再生困难,Müller细胞是参与视网膜发育、受损及再生过程的重要胶质细胞。近年研究证明,Müller细胞是视网膜神经元的内源性替代来源,为视网膜神经再生的优秀靶标。本文根据视网膜神经再生过程、Müller细胞与视网膜神经再生相关因素进行综述,为神经再生研究提供新方向。Retinal degenerative diseases,a type of blinding eye diseases in which retinal neuron apoptosis is the main pathological process.Neuronal cells cannot be regenerated after damage,Müller cells are important glial cells of the retina and involved in retinal development,damage,and regeneration process.In recent years,studies have proved that Müller cells are an endogenous alternative source for stimulating damaged retinal neurons and an excellent target for retinal nerve regeneration.This article reviews the related factors of Müller cells and retinal nerve regeneration,and provides a new direction for nerve regeneration research.

关 键 词：视网膜退行性疾病 胶质细胞 MÜLLER细胞 神经再生 视网膜神经元 

分 类 号：R74[医药卫生—神经病学与精神病学]