阿加曲班与阿司匹林对前循环急性脑梗死早期进展患者疗效及NIHSS、BI评分的影响  

Effect of Agartroban and Aspirin on early Progress of Acute Cerebral Infarction in Anterior Circulation Patients and NIHSS,BI Score

作　　者：岳丽蕾 YUE Lilei(Liaoning Health Industry Group Iron Coal General Hospital,Tieling 112700,China)

机构地区：[1]辽宁省健康产业集团铁煤总医院,辽宁铁岭112700

出　　处：《中国医药指南》2020年第35期111-112,共2页Guide of China Medicine

摘　　要：目的观察对处于早期进展阶段的前循环急性脑梗死患者给予阿加曲班、阿司匹林联用疗法的效果及对其美国国立卫生院神经功能缺损(NIHSS)评分、日常生活能力Barthel指数量表(BI)调节作用。方法本研究纳入80例处于早期进展阶段的前循环急性脑梗死患者为对象,纳入时间是2018年7月至2019年7月,按照不同的治疗方案进行分组,即A组(n=40例,单纯给予阿司匹林口服治疗)、B组(n=40例,给予阿加曲班、阿司匹林联用疗法),比较两组的疗效情况。结果两组治疗前的NIHSS评分、BI指数、肿瘤坏死因子α(TNF–α)水平、C反应蛋白(CRP)水平对比无差异,P>0.05。但治疗后B组NIHSS评分较A组低,BI指数较A组高,差异有统计学意义,P<0.05;治疗后B组的TNF-α水平与CRP水平均较A组低,对比存在显著的差异,P<0.05。A组本次治疗的总有效率是75.00%,较B组的95.00%低,差异显著,P<0.05。结论对处在早期进展阶段的前循环急性脑梗死患者积极采取阿加曲班、阿司匹林联用疗法,可显著改善其神经功能缺损及炎症状态,提高患者的生活自理能力,临床疗效颇为显著。Objective To observe the effect of the combination therapy on the first-cycle acute cerebral infarction in the early stage of progressive cerebral infarction,and to adjust the NIHSS score and the BI score.Methods The study included 80 patients with pre-circulating acute cerebral infarction in the early stage of progress.The included time was July 2018 to July 2019,and the scientific grouping was carried out according to different treatment protocols,namely:group A(n=40,only given aspirin for oral treatment),group B(n=40,administration of agomelas and aspirin)to compare the effect of 2 groups.Results There was no difference in NIHSS score,BI index,TNF-αlevel and CRP level before treatment between the two groups,P>0.05.However,the NIHSS score of group B was lower than that of group A after treatment,and the BI index was higher than that of group A.The difference was statistically significant(P<0.05).After treatment,the level of TNF-αand CRP in group B were lower than those in group A.The difference was P<0.05.The total effective rate of this treatment in group A was 75.00%,which was lower than that of group B,which was significantly different,P<0.05.Conclusion Agartroban and aspirin combined therapy can significantly improve the neurological deficit and inflammation in patients with acute cerebral infarction of anterior circulation in the early stage of progress.The patient's self-care ability and clinical effect are significant.

关 键 词：前循环急性脑梗死 早期进展 阿加曲班 阿司匹林 NIHSS评分 BI评分 

分 类 号：R743.3[医药卫生—神经病学与精神病学]