晚期贲门癌患者应用PD-1抗体(SHR-1210)致重度苔藓样皮疹1例  

Severe Lichenoid Dermatitis Caused by Immune Checkpoint Inhibitor SHR-1210 in the Patient with Advanced Gastric Cardia Cancer:A Case Report

作　　者：杨荷 陈晓琦[1] 张传雷[1] 冉小柯 陈欣菊[1] YANG He;CHEN Xiao-qi;ZHANG Chuan-lei;RAN Xiao-ke;CHEN Xin-ju(The First Affiliated Hospital of Henan University of Chinese medicine,Zhengzhou 450000 Henan,China)

机构地区：[1]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中医肿瘤学杂志》2021年第1期43-45,42,共4页Journal of Oncology in Chinese Medicine

基　　金：河南省中医药科学研究专项课题(编号:2019JDZX079)。

摘　　要：免疫检查点抑制剂已广泛应用于肿瘤的临床治疗,其相关免疫不良反应也逐步受到临床医师的关注。皮肤不良反应是其中常见不良反应之一。本文报道1例晚期贲门癌患者使用免疫检查点抑制剂(PD-1抗体)卡瑞利珠单抗治疗时发生重度苔藓样皮疹,采用中西医结合治疗后基本痊愈的病例。Immune checkpoint inhibitors have been widely used in the clinical treatment of tumors,and their related adverse immune reactions have gradually attracted the attention of clinicians.Skin adverse reactions are one of the common adverse reactions.This article reported a case of a patient with advanced gastric cardia cancer who was treated with immune checkpoint inhibitor SHR-1210(anti-PD-1 antibody)and developed into a severe lichenoid dermatitis,and the patient was basically cured after treatment with integrated traditional Chinese and western medicine.

关 键 词：免疫检查点抑制剂 皮肤不良反应 苔藓样皮疹 

分 类 号：R735.2[医药卫生—肿瘤]