尼莫地平联合鼠神经生长因子治疗对脑出血患者脑水肿带体积、神经功能及血清炎性因子水平的影响  

Effects of nimodipine combined with mouse nerve growth factor on cerebral edema zone volume,nerve function and serum inflammatory factors levels in patients with cerebral hemorrhage

作　　者：朱竞繁 王霞 ZHU Jingfan;WANG Xia(Department of Neurology,the Sixth People′s Hospital of Huizhou,Huizhou 516211,Guangdong province,China)

机构地区：[1]惠州市第六人民医院神经内科,广东省惠州市516211

出　　处：《内科》2020年第6期680-682,共3页Internal Medicine

基　　金：惠州市科技计划项目(2018Y266)。

摘　　要：目的探讨尼莫地平联合鼠神经生长因子治疗对脑出血患者脑水肿带体积、神经功能及血清炎性因子水平的影响。方法选取2018年6月至2019年12月我院收治的脑出血患者120例为研究对象,按照随机数字法分为实验组和对照组,每组60例。对照组患者给予脑出血常规治疗,实验组患者在对照组治疗的基础上给予尼莫地平+鼠神经生长因子治疗,疗程14 d。比较两组患者治疗前后的脑水肿带体积、神经功能(NIHSS评分)及血清炎性因子(TNF-α、IL-1β)水平。结果治疗前,两组患者的脑水肿带体积、NIHSS评分比较差异无统计学意义(P>0.05);治疗14 d后,两组患者的脑水肿带体积缩小、NIHSS评分显著降低,实验组患者的脑水肿带体积显著小于对照组、NIHSS评分显著低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的TNF-α、IL-1β水平比较差异无统计学意义(P>0.05);治疗14 d后,两组患者的TNF-α、IL-1β水平均显著降低,实验组患者的水平显著低于对照组,差异有统计学意义(P<0.05)。结论在常规治疗的基础上加用尼莫地平与鼠神经生长因子治疗,能够更有效地缩小脑出血患者的脑水肿带体积、改善神经功能、降低血清炎性因子水平,促进患者康复。Objective To investigate the effect of nimodipine combined with mouse nerve growth factor on cerebral edema zone volume,nerve function and serum inflammatory factors levels in patients with cerebral hemorrhage.Methods A total of 120 patients with cerebral hemorrhage admitted to our hospital from June 2018 to December 2019 were selected as the research objects.They were divided into observation group and control group according to the random number method,with 60 cases in each group.The control group was given conventional treatment for cerebral hemorrhage,based on which the experimental group was given nimodipine plus mouse nerve growth factor for treatment,with a fourteen-day treatment course.The brain edema zone volume,nerve function(NIHSS score)and serum inflammatory factors(TNF-α,IL-1β)levels before and after treatment were compared between the two groups.Results Before treatment,there were no statistically significant differences in brain edema zone volume and NIHSS scores between the two groups(P>0.05).After 14 days of treatment,the brain edema zone volume and NIHSS scores of the two groups decreased significantly,and the edema zone volume of the experimental group was significantly smaller than that of the control group,whereas the NIHSS score was significantly lower than that of the control group,with statistically significant differences(P<0.05).Before treatment,there were no statistically significant differences in the levels of TNF-αand IL-1βbetween the two groups(P>0.05).After 14 days of treatment,the levels of TNF-αand IL-1βin the two groups significantly decreased.The levels mentioned above in the experimental group were significantly lower than those in the control group,with statistically significant differences(P<0.05).Conclusion Additionally employing nimodipine and mouse nerve growth factor based on the conventional treatment can more effectively reduce the volume of cerebral edema in patients with cerebral hemorrhage,improve nerve function,decrease serum inflammatory factors levels,and t

关 键 词：脑出血 尼莫地平 注射用鼠神经生长因子 脑水肿带体积 神经功能 炎性因子水平 

分 类 号：R743.34[医药卫生—神经病学与精神病学]