TKTL1 mRNA、RBM6 mRNA在喉癌患者病灶组织中的表达及对预后的影响  

Expression of TKTL1 mRNA and RBM6 mRNA in Lesion Tissue of LaryngealCarcinoma Patients and Its Effect on Prognosis

作　　者：张志德 王晓宇[1] 孔德杰[1] 陈海岩[1] 闻克银[1] ZHANG Zhide;WANG Xiaoyu;KONG Dejie(Nanyang Second People's Hospital,Nanyang,473000)

机构地区：[1]河南省南阳市第二人民医院,473000

出　　处：《实用癌症杂志》2021年第1期72-76,共5页The Practical Journal of Cancer

摘　　要：目的探讨类转酮醇酶1(TKTL1)mRNA、RNA结合基序蛋白6(RBM6)mRNA在喉癌患者病灶组织中的表达及对预后的影响。方法选取喉癌患者102例作为研究对象,其中癌组织作为观察组,癌旁正常组织作为对照组。比较两组TKTL1 mRNA、RBM6 mRNA水平,分析TKTL1 mRNA与RBM6 mRNA相关性,评价两者与喉癌患者临床病理因素的关系,随访3年,统计喉癌患者3年生存率,对比不同TKTL1 mRNA、RBM6 mRNA表达患者3年生存率。结果观察组TKTL1 mRNA水平高于对照组,RBM6 mRNA水平低于对照组(P<0.05);TKTL1 mRNA与RBM6 mRNA呈负相关(P<0.05);喉癌患者临床分期、淋巴结转移、复发与TKTL1 mRNA呈正相关,与RBM6 mRNA呈负相关,组织学分化程度与TKTL1 mRNA呈负相关,与RBM6 mRNA呈正相关(P<0.05);TKTL1 mRNA高表达患者3年生存率低于低表达患者,RBM6 mRNA高表达患者3年生存率高于低表达患者(P<0.05)。结论TKTL1 mRNA、RBM6 mRNA在喉癌患者病灶组织中呈反向变化,且表达水平与临床分期、淋巴结转移、复发及预后生存关系密切,可能参与喉癌的恶性进展过程。Objective To investigate the expression of transketolase-like 1(TKTL1)mRNA and RNA binding motif protein 6(RBM6)mRNA in the lesions of patients with laryngeal carcinoma and their influence on the prognosis.Methods 102 patients with laryngeal cancer were selected as the research objects,among which the cancer tissue was used as the observation group,and the normal tissue adjacent to the cancer was used as the control group.The levels of TKTL1 mRNA and RBM6 mRNA were compared between the 2 groups,the correlation between TKTL1 mRNA and RBM6 mRNA was analyzed,and the relationship between the two and the clinicopathological factors of patients with laryngeal cancer was evaluated.After 3 years of follow-up,the 3-year survival rate of patients with laryngeal cancer was counted,and the 3-year survival rate of patients with different expression of TKTL1 mRNA and RBM6 mRNA was compared.Results The TKTL1 mRNA level of the observation group was higher than that of the control group,and the RBM6 mRNA level was lower than that of the control group(P<0.05).TKTL1 mRNA was negatively correlated with RBM6 mRNA(P<0.05).The clinical s tage,lymph node metastasis and recurrence of patients with laryngeal cancer are positively correlated with TKTL1 mRNA,and negatively correlated with RBM6 mRNA.The degree of histological differentiation was negatively correlated with TKTL1 mRNA and positively correlated with RBM6 mRNA(P<0.05).The 3-year survival rate of patients with high expression of TKTL1 mRNA was lower than that of patients with low expression,and the 3-year survival rate of patients with high expression of RBM6 mRNA was higher than that of patients with low expression(P<0.05).Conclusion The changes of TKTL1 mRNA and RBM6 mRNA in the lesion tissue of patients with laryngeal cancer are reversed,and their expression levels are closely related to clinical stage,lymph node metastasis,recurrence and prognostic survival,and may be involved in the malignant progression of laryngeal cancer.

关 键 词：类转酮醇酶1 RNA结合基序蛋白6 喉癌 癌组织 癌旁正常组织 生存率 

分 类 号：R739.65[医药卫生—肿瘤]