残余瘤大小对Ⅲc~Ⅳ期卵巢透明细胞癌患者预后的影响  

Effect of Residual Tumor Size on Prognosis of Patients with StageⅢc~ⅣOvarian Clear Cell Carcinoma

作　　者：汪洋[1] 蔡红兵[1] WANG Yang;CAI Hongbing(Zhongnan Hospital of Wuhan University,Hubei Cancer Clinical Study Center,Hubei Key Laboratory of Tumor Biological Behaviors,Wuhan,430071)

机构地区：[1]武汉大学中南医院,湖北省肿瘤医学研究中心,肿瘤生物学行为湖北省重点实验室,430071

出　　处：《实用癌症杂志》2021年第1期100-103,共4页The Practical Journal of Cancer

摘　　要：目的探讨术后残余瘤大小对Ⅲc~Ⅳ期卵巢透明细胞癌患者预后的影响。方法回顾性分析42例Ⅲc~Ⅳ期卵巢透明细胞癌患者的临床资料,按照残余瘤大小将患者分为3组,通过方差分析和卡方检验来判断临床特征在组别间的分布差异,用Kaplan-Meier生存曲线来评估患者的生存率,组间差异采用log-rank分析方法,并用COX单因素和多因素分析判断影响患者预后的独立危险因素。结果对患者的临床特征进行比较,发现腹水和无铂间期分布存在差异,其余因素的分布无统计学差异。生存分析发现无残余瘤组、残余瘤≤1 cm组和残余瘤>1 cm组患者的3年OS率分别为60.2%、10.7%和0.0%(P=0.023)以及1年PFS率分别为75.0%、44.3%和25.0%(P=0.000)。单因素分析发现残余瘤和无铂间期均影响患者的OS和PFS;COX多因素分析发现无铂间期是影响患者OS的独立危险因素,而影响患者PFS的独立危险因素为残余瘤和无铂间期。结论术后残余瘤≤1 cm可提高Ⅲc~Ⅳ期卵巢透明细胞癌患者的PFS,但只有在术后无残余瘤时才能提高患者的OS。Objective To investigate the prognosis of patients with stageⅢc~Ⅳovarian clear cell carcinoma after residual tumor size.Methods The clinical data of 42 patients with stageⅢc~Ⅳovarian clear cell carcinoma were retrospectively analyzed.The patients were divided into 3 groups according to the residual tumor size.The analysis of variance and chi-square test were used to judge the distribution of clinical features among groups.The Kaplan-Meier survival curve was used to evaluate the survival rate of patients and the difference between the 2 groups were analyzed by log-rank analysis.COX univariate and multivariate analyses were used to determine independent risk factors for prognosis.Results The clinical characteristics of the patients were compared.It was found that there was a difference in the distribution of ascites and platinum-free interval,the distribution of other factors was not statistically different.Survival analysis found that the 3-year OS rates of patients without residual tumor group,residual tumor≤1 cm group and residual tumor>1 cm group were 60.2%,10.7%and 0.0%,respectively(P=0.023)and 1 year PFS rate were 75.0%,44.3%and 25.0%(P=0.000).Univariate analysis showed that both residual tumor and platinum-free interval affected OS and PFS;COX multivariate analysis found that no platinum interval was an independent risk factor for OS,and the independent risk factors for PFS were residual tumor and platinum-free interval.Conclusion Residual tumor≤1 cm after operation could improve the PFS of patients with stageⅢc~Ⅳovarian clear cell carcinoma,but only no residual tumors could improve the patient's OS.

关 键 词：卵巢透明细胞癌 残余瘤 无铂间期 腹水 预后 

分 类 号：R737.31[医药卫生—肿瘤]