脂肪肝并发肝功能损害的相关危险因素及防治干预措施  

Risk factors associated with fatty liver complicated by liver damage and preventive and therapeutic measures

作　　者：徐霁 章红燕 Xu Ji;Zhang Hongyan(Department of Liver,the Fifth People's Hospital of Wuxi City,214011,China)

机构地区：[1]无锡市第五人民医院肝科,214011

出　　处：《国际护理学杂志》2021年第2期224-227,共4页international journal of nursing

基　　金：无锡市医院管理中心科研项目(YGZXH1308)。

摘　　要：目的探讨脂肪肝并发肝功能损害的相关危险因素,为防治干预措施的制定提供依据。方法选取2016年7月至2018年10月在该院就诊的脂肪肝并发肝功能损害患者46例为观察组,并选取同期脂肪肝患者46例为对照组,比较两组单因素分析结果,并进行Logistic多因素分析。结果观察组超重、肥胖、高血压、慢性饮酒、吸烟、饮酒所占比例均高于对照组,低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)及血尿酸(UA)水平较高,高密度脂蛋白胆固醇(HDL-C)水平及经常锻炼所占比例较低,差异有统计学意义(P<0.05);经Logistic分析,超重、肥胖、慢性饮酒、高血压、吸烟及LDL-C、FBG和UA水平升高是脂肪肝合并肝功能损害发生的危险因素(OR>1,P<0.05);HDL-C水平升高及经常锻炼为脂肪肝合并肝功能损害发生保护因素(OR<1,P<0.05)。结论饮酒、吸烟、慢性饮酒、高血压、肥胖、超重、锻炼及LDL-C、FBG、UA和HDL-C水平与脂肪肝并发肝功能损害有着密切的关系,应通过加强锻炼、合理膳食等方法控制和预防脂肪肝合并肝功能损害发展。Objective To explore the risk factors of fatty liver combined with liver damage,and to provide evidence for the development of preventive and therapeutic interventions.Methods Forty-six patients with fatty liver complicated with liver function impairment admitted to Wuxi Fifth People's Hospital from July 2016 to October 2018 were selected as the observation group,and 46 patients with fatty liver disease during the same period were selected as the control group.Univariate analysis was performed between the two groups and Logistic multivariate analysis was performed.Results The proportions of overweight,obesity,hypertension,chronic drinking,smoking and alcohol consumption in the observation group were higher than those in the control group.The levels of low density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG)and blood uric acid(UA)in the observation group were higher than those in the control group.The proportions of high density lipoprotein cholesterol(HDL-C)and regular exercise were lower in the observation group,the differences were statistically significant(P<0.05).Logistic analysis showed that overweight,obesity,chronic drinking,hypertension,smoking,and elevated levels of LDL-C,FBG and UA were the risk factors for fatty liver with liver function damage(OR>1,P<0.05).The elevated HDL-C levels and conventional exercise were protective factors for fatty liver and liver damage(OR<1,P<0.05).Conclusions Drinking,smoking,chronic drinking,hypertension,obesity,overweight,exercise and the levels of LDL-C,FBG,UA and HDL-C are closely related to fatty liver complicated with liver function impairment.Therefore,it is necessary to control and prevent the development of fatty liver complicated with liver function impairment by strengthening exercise and reasonable diet.

关 键 词：脂肪肝 肝功能损害 

分 类 号：R575[医药卫生—消化系统]