侵袭性伪足和MMP-14在肿瘤发病机制中的研究进展  

Progress in the research on the roles of invadopodia and metalloproteinase-14 in tumorigenesis and cancer development

作　　者：裴雪艳(综述) 王琰(审校)[1] PEI Xueyan;WANG Yan(Department of Otolaryngology&Head and Neck Surgery,the First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning,China)

机构地区：[1]中国医科大学附属第一医院耳鼻咽喉头颈外科,辽宁沈阳110001

出　　处：《山东大学耳鼻喉眼学报》2020年第6期129-134,共6页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：辽宁省科学技术基金(20170541026)。

摘　　要：恶性肿瘤仍是目前医学难以攻克的课题,原发肿瘤是否已经发生转移,直接影响肿瘤患者的预后。基质金属蛋白酶14(MMP-14)参与正常细胞的生理功能和肿瘤相关过程,如细胞迁移、炎症、侵袭、转移、血管生成和扩散。侵袭性伪足是恶性肿瘤细胞膜形成的一种向外凸起的、具有降解细胞外基质(ECM)能力的膜型突起结构。两者在肿瘤的发生发展中具有重要作用。Malignant tumors are still enigmatic in the field of medical science.The prognosis of cancer patients largely depends on whether the primary tumor has metastasized or not.Matrix metalloproteinase-14(MMP-14)is involved in physiological functions of normal cells and in tumor-related processes,such as cell migration,inflammation,invasion,metastasis,and angiogenesis.Invadopodia are protrusions of the plasma membranes of malignant tumor cells,with the ability to degrade the extracellular matrix.Thus,MMP-14 and invadopodia have critical roles in tumorigenesis and cancer progression.

关 键 词：金属蛋白酶-14 侵袭性伪足 肿瘤 侵袭转移 

分 类 号：R737[医药卫生—肿瘤]