从调节胆固醇代谢角度探讨阿尔茨海默病及中医药的防治  

Discussion on the Prevention and Treatment of Alzheimer’s Disease by Traditional Chinese Medicine from the Perspective of Regulating Cholesterol Metabolism

作　　者：谢丽媛 吴明安 李伟荣[1] 王宏[1] 王奇[1] XIE Liyuan;WU Mingan;LI Weirong;WANG Hong;WANG Qi(Science and Technology Inmovation Center,Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)

机构地区：[1]广州中医药大学科技创新中心,广东广州510405

出　　处：《中药新药与临床药理》2021年第1期144-148,共5页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金项目(81573638,82074505);广东省自然科学基金项目(2017A030313666);广东省普通高校重点实验室项目(2019KSYS005);广州市科技创新委员会重点实验室项目(201805010005)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)与基础性代谢疾病如高血脂、糖尿病等相关。高胆固醇血症是AD发病的重要风险因素,其引起的胆固醇代谢异常会加剧AD进程。该文从27-羟基胆固醇(27-hydroxycholesterol,27-OH)入手,对高胆固醇血症对AD的相关致病机制进行阐述,并综述降脂药物防治AD的研究进展,特别是中医药防治AD所取得的成果。AD是涉及多因素、多环节的一种复杂病症,分型防治尤为重要。从调节胆固醇代谢角度入手,可为药物防治AD提供新思路。Alzheimer′s disease(AD)is related to basic metabolic diseases such as hyperlipidemia,hypertension,diabetes,etc. Hypercholesterolemia is an important risk factor for AD,and abnormal cholesterol metabolism caused by hypercholesterolemia will aggravate AD progress. This article starts with 27-hydroxycholesterol(27-OH),elaborates the related pathogenic mechanism between hypercholesterolemia and AD, and reviews the research progress of lipid-lowering drugs for preventing and treating AD,especially the results achieved by Chinese medicine in the prevention and treatment of AD. AD is a complex disease involving multiple factors and multiple links. Typed prevention and treatment are particularly important. Standing from the perspective of regulating cholesterol metabolism can provide new ideas for drug prevention and treatment of AD.

关 键 词：阿尔茨海默病 高胆固醇血症 降脂药物 中医药疗法 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R285.5[医药卫生—临床医学]