维生素B6联合叶酸治疗缺血性脑卒中伴高Hcy血症疗效及对神经功能、血Hcy水平的影响  

Effect of vitamin B6 combined with folic acid in the treatment of ischemic stroke with hyperhcyemia and its effect on nerve function and blood Hcy level

作　　者：朱兆武 姜爽[1] 郑敏[1] 刘伟娜[1] 孙亚男 ZHU Zhaowu;JIANG Shuang;ZHENG Min;LIU Weina;SUN Ya'nan(Department of Encephalopathy,Jiamusi Traditional Chinese Medicine Hospital in Heilongjiang Province,Jiamusi 154000,China)

机构地区：[1]黑龙江省佳木斯市中医院脑病科,黑龙江佳木斯154000

出　　处：《中国现代医生》2020年第35期5-7,11,共4页China Modern Doctor

基　　金：中华国际科学交流基金会检验检测科技专项基金(Z2019LHLJ011)。

摘　　要：目的针对缺血性脑卒中伴高Hcy血症,研究分析维生素B6联合叶酸治疗的临床效果及对神经功能、血Hcy水平的影响。方法以2019年1~12月我院收治的74例缺血性脑卒中伴高Hcy血症患者为研究对象,采用随机数字表法分为观察组和对照组,每组各37例。对照组实施常规治疗方法,观察组在常规治疗的基础上联合叶酸治疗,比较分析两组的临床疗效、神经功能缺损情况、日常生活状态以及血Hcy水平。结果观察组总有效率(94.59%)明显高于对照组(78.38%),差异有统计学意义(P<0.05)。治疗前两组的NIHSS评分及ADL评分比较,差异无统计学意义(P>0.05),治疗后观察组的NIHSS评分明显低于对照组,ADL评分明显高于对照组,差异有统计学意义(P<0.05)。治疗前两组的血Hcy水平比较,差异无统计学意义(P>0.05),治疗后观察组的血Hcy水平明显低于对照组,差异有统计学意义(P<0.05)。结论维生素B6联合叶酸治疗能增加缺血性脑卒中伴高Hcy血症患者的临床疗效,改善神经功能,调节血Hcy水平,值得推广。Objective To study and analyze the clinical effect of vitamin B6 combined with folic acid treatment and its effect on nerve function and blood Hcy level for ischemic stroke with hyperhcyemia.Methods A total of 74 patients with ischemic stroke with hyperhcyemia in our hospital from January to December 2019 were taken as subjects.They were randomly divided into the observation group and the control group,with 37 cases in each group.The control group received routine treatment.The observation group received folic acid treatment on the basis of conventional treatment.The clinical efficacy,neurological function defect,state of daily life and blood Hcy level between the two groups were compared and analyzed.Results The total effective rate(94.59%)in the observation group was significantly higher than(78.38%)in the control group,and the difference was significant(P<0.05).There was no significant difference in NIHSS score and ADL score between the two groups before treatment(P>0.05).The NIHSS score in the observation group was significantly lower than that in the control group after treatment,and the ADL score in the observation group was obviously higher than that in the control group,and the differences were significant(P<0.05).There was no significant difference in blood Hcy levels between the two groups before treatment(P>0.05).The blood Hcy level in the observation group was significantly lower than that in the control group after treatment,and the difference was significant(P<0.05).Conclusion Vitamin B6 combined with folic acid treatment can increase the clinical efficacy of patients with ischemic stroke and hyperhcyemia,improve nerve function,and regulate blood Hcy levels.It is worthy of promotion.

关 键 词：维生素B6 叶酸 缺血性脑卒中 高HCY血症 神经功能 临床疗效 

分 类 号：R743[医药卫生—神经病学与精神病学]