化疗药治疗肝细胞癌的研究进展  

Chemotherapeutic drugs in the treatment of hepatocellular carcinoma:research advances

作　　者：田塬 唐贵菊 王继婷 苏松 宋敏 李亚玲 TIAN Yuan;TANG Gui-ju;WANG Ji-ting;SU Song;SONG Min;LI Ya-ling(Department of Clinical Pharmacy,School of Pharmacy,Southwest Medical University,Luzhou 646000,China;Department of Liver and Gallbladder,Affiliated Hospital of Southwest Medical University,Luzhou 646000,China;Department of Medical Laboratory,Affiliated Hospital of Southwest Medical University,Luzhou 646000,China;Department of Pharmacy,Affiliated Hospital of Southwest Medical University,Luzhou 646000,China)

机构地区：[1]西南医科大学药学院临床药学系,泸州646000 [2]西南医科大学附属医院肝胆科,泸州646000 [3]西南医科大学附属医院医学检验部,泸州646000 [4]西南医科大学附属医院药学部,泸州646000

出　　处：《国际药学研究杂志》2020年第12期1088-1093,共6页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(81803019)。

摘　　要：肝细胞癌是一种较为常见的原发性肝癌,由于早期诊断不足加上手术切除的适用范围窄,使用化疗药物仍是中晚期肝癌的重要治疗手段之一。不同化疗药物因种类不同而疗效差异大,毒副作用不一致,耐药性也不尽相同。已有研究发现,除研制新药外,降低化疗药物毒副作用和耐药性对提高肝癌治疗效果起关键作用。本文归纳了降低化疗药治疗原发性肝癌的毒副作用及耐药性方面的研究进展,旨在为临床医师治疗肝癌时选择合理的化疗方案提供参考。Hepatocellular carcinoma(HCC)is a common type of primary liver cancer.Due to the lack of early diagnosis and the narrow scope of application of surgical resection,chemotherapeutic drugs are still one of the significant treatments for advanced HCC.Different chemotherapeutic drugs,however,have different therapeutic effects,side effects and drug resistance.Therefore,in addition to the development of new drugs,some studies have found that reducing the toxic and side effects of chemotherapeutic drugs and chemotherapy resistance can play a key role in improving the therapeutic effect of HCC.This paper summarizes the research prog⁃ress in reducing adverse reactions and drug resistance of chemotherapeutic drugs in the treatment of HCC,so as to provide a reference for clinicians to choose a reasonable chemotherapy regimen for the treatment of liver cancer.

关 键 词：肝细胞癌 化疗 不良反应 耐药 化疗方案 

分 类 号：R735.7[医药卫生—肿瘤] R969.3[医药卫生—临床医学]