Foxp3+调节性T细胞及程序性死亡受体1在胃癌组织中的表达及其临床病理意义  

Expression and Clinicopathological Significance of Foxp3+Regulatory T Cells and Programmed Death Receptor 1 in Gastric Cancer

作　　者：鞠晓静 JU Xiao-jing(Department of Pathology,Wuqing District Traditional Chinese Medicine Hospital,Tianjin 301700,China)

机构地区：[1]天津市武清区中医医院病理科,天津301700

出　　处：《医学信息》2021年第2期105-107,112,共4页Journal of Medical Information

摘　　要：目的观察胃癌组织及癌旁正常组织中Foxp3+调节性T细胞(Foxp3+Tregs)及程序性死亡受体1(PD1)的表达情况,分析两者在胃癌组织中的表达情况与患者临床病理的关系。方法选取2011年1月~2016年12月我院收治的121例胃癌患者,取其胃癌组织及癌旁正常组织作为标本,采用免疫组化的方法测定患者胃癌组织及癌旁正常组织中Foxp3+Tregs和PD1的表达情况。随访3年,比较Foxp3+Tregs、PD1阳性表达与阴性表达患者的生存情况。结果胃癌组织中Foxp3+Tregs、PD1阳性表达率分别为61.88%、64.46%,癌旁正常组织中阳性表达率分别为0.83%、1.65%,胃癌组织Foxp3+Tregs、PD1阳性表达率高于癌旁正常组织,差异有统计学意义(P<0.05)。不同性别、年龄、肿瘤大小及病变位置胃癌组织中Foxp3+Tregs和PD1的表达比较,差异无统计学意义(P>0.05);不同肿瘤分化程度、TNM分期及淋巴结转移胃癌组织中Foxp3+Tregs和PD1的表达比较,差异有统计学意义(P<0.05);胃癌组织中Foxp3+Tregs与PD1呈正相关(r=0.527,P<0.05);随访3年,Foxp3+Tregs与PD1阳性表达患者生存率低于阴性表达患者,差异有统计学意义(P<0.05)。结论 Foxp3+Tregs与PD1可作为判断患者病情进展及预后的生物学标志,肿瘤分化程度、TNM分期及淋巴结是否转移均会影响其表达情况,Foxp3+Tregs与PD1阳性表达会影响患者的生存率。Objective To observe the expression of Foxp3+regulatory T cells(Foxp3+Tregs)and programmed death receptor 1(PD1)in gastric cancer tissue and normal tissues adjacent to the cancer,and to analyze the expression of the two in gastric cancer tissue and the clinical pathology of patients relationship.Methods A total of 121 gastric cancer patients admitted to our hospital from January 2011 to December 2016 were selected,and their gastric cancer tissues and normal adjacent tissues were taken as specimens.Immunohistochemical method was used to determine the expression of Foxp3+Tregs and PD1 in gastric cancer tissues and adjacent normal tissues.Follow-up for 3 years,compare the survival of Foxp3+Tregs,PD1 positive and negative expression patients.Results The positive expression rates of Foxp3+Tregs and PD1 in gastric cancer tissues were 61.88%and 64.46%,respectively,and the positive expression rates in normal tissues adjacent to cancer were 0.83%and 1.65%,respectively.The positive expression rate of Foxp3+Tregs and PD1 in gastric cancer tissue was higher than that in normal tissues adjacent to cancer,the difference was statistically significant(P<0.05).There was no statistically significant difference in the expression of Foxp3+Tregs and PD1 in gastric cancer tissues of different genders,ages,tumor sizes and lesion locations(P>0.05);The expressions of Foxp3+Tregs and PD1 in gastric cancer tissues with different tumor differentiation,TNM stages and lymph node metastasis were significantly different(P<0.05);Foxp3+Tregs in gastric cancer tissues were positively correlated with PD1(r=0.527,P<0.05);After 3 years of follow-up,the survival rate of Foxp3+Tregs and PD1 positive expression patients was lower than that of negative expression patients,the difference was statistically significant(P<0.05).Conclusion Foxp3+Tregs and PD1 can be used as biological markers for judging the patient's disease progression and prognosis.The degree of tumor differentiation,TNM stage and lymph node metastasis will all affect their expression.The

关 键 词：胃癌 FOXP3+调节性T细胞 程序性死亡受体1 

分 类 号：R735.2[医药卫生—肿瘤] R730.2[医药卫生—临床医学]