Therapeutic applications of genetic code expansion  

作　　者：Yujia Huang Tao Liu 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing,100191,China

出　　处：《Synthetic and Systems Biotechnology》2018年第3期150-158,共9页合成和系统生物技术（英文）

基　　金：We thank the following agencies for financial support on related ongoing projects in our lab:National Key Research and Development Program of China(No.2016YFA0201400);the National Natural Science Foundation of China(21778005);Peking University Health Science Center(BMU20160537 and BMU2017QQ006);Youth Thousand-Talents Program of China。

摘　　要：In nature,a limited,conservative set of amino acids are utilized to synthesize proteins.Genetic code expansion technique reassigns codons and incorporates noncanonical amino acids(ncAAs)through orthogonal aminoacyltRNA synthetase(aaRS)/tRNA pairs.The past decade has witnessed the rapid growth in diversity and scope for therapeutic applications of this technology.Here,we provided an update on the recent progress using genetic code expansion in the following areas:antibody-drug conjugates(ADCs),bispecific antibodies(BsAb),immunotherapies,long-lasting protein therapeutics,biosynthesized peptides,engineered viruses and cells,as well as other therapeutic related applications,where the technique was used to elucidate the mechanisms of biotherapeutics and drug targets.

关 键 词：Genetic code expansion Noncanonical amino acids BIOTHERAPEUTICS Antibody-drug conjugates Live-attenuated vaccines 

分 类 号：O62[理学—有机化学]