老年急性孤立性脑桥梗死患者早期运动功能缺损进展的相关危险因素分析  

Risk factors for progressive early motor deficit in elderly acute pontine infarction patients

作　　者：徐辉[1] 宋晶晶[1] 陈静[1] 邢媛媛[1] 陈帅 陈思 白宏英[1] Xu Hui;Song Jingjing;Chen Jing;Xing Yuanyuan;Chen Shuai;Chen Si;Bai Hongying(Department of Neurology,No.2 Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China)

机构地区：[1]郑州大学第二附属医院神经内科,450000

出　　处：《中华老年心脑血管病杂志》2021年第1期67-70,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨老年急性孤立性脑桥梗死患者早期运动功能缺损进展的预测因素。方法选择郑州大学第二附属医院神经内科收治的资料完整的老年急性孤立性脑桥梗死患者95例,根据病情是否进展将患者分为进展性运动功能缺损(progressive motor deficits,PMD)组31例(32.6%)和未进展组64例。PMD为发病1周内,美国国立卫生研究院卒中量表(NIHSS)中运动项目评分较入院增加≥1分。比较2组临床资料特点,用多变量logistic回归分析PMD的预测因素。结果PMD组女性、入院NIHSS评分、下部脑梗死和梗死累及脑桥腹侧表面比例明显高于非进展组,差异有统计学意义[58.1%vs 35.9%、(4.13±1.50)分vs(3.58±1.14)分、45.2%vs 17.2%、80.6%vs 53.1%,P<0.05,P<0.01]。多变量logistic回归分析显示,梗死累及脑桥腹侧表面(OR=3.512,95%CI:1.146~10.766,P=0.028)和下部脑梗死(OR=6.029,95%CI:1.374~26.450,P=0.017)是PMD的独立危险因素。结论梗死累及脑桥腹侧表面和下部脑梗死可作为孤立性脑桥梗死早期神经功能缺损进展的预测指标。Objective To study the risk factors for progressive motor deficit(PMD)in elderly acute pontine infarction patients.Methods Ninety-five elderly acute pontine infarction patients admitted to our hospital were divided into PMD group(n=31)and PMD-free group(n=64).The patients were diagnosed as PMD if their increased NIHSS score was≥1 in the first week after onset of PMD.The characteristics of their clinical data were compared and the risk factors for PMD were analyzed by multivariate logistic regression analysis.Results The rate of female patients,NIHSS score on admission,rate of lower cerebral infarction and infarction involving the ventral surface of pons were significantly higher in PMD group than in PMD-free group(58.1%vs 35.9%,4.13±1.50 vs 3.58±1.14,45.2%vs 17.2%,80.6%vs 53.1%,P<0.05,P<0.01).Multivariate logistic regression analysis showed that infarction involving the ventral surface of pons and lower cerebral infarction were the independent risk factors for PMD in elderly acute pontine infarction patients(OR=3.512,95%CI:1.146-10.766,P=0.028;OR=6.029,95%CI:1.374-26.450,P=0.017).Conclusion Infarction involving the ventral surface of pons and lower cerebral infarction are the risk factors for PMD in elderly acute pontine infarction patients.

关 键 词：脑桥 脑梗死 动作障碍 磁共振成像 危险因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]