Coordinated regulation for nature products discovery and overproduction in Streptomyces  

作　　者：Qun Zhou Shuqing Ning Yunzi Luo 

机构地区：[1]Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education),School of Chemical Engineering and Technology,Tianjin University,Tianjin,300072,China [2]Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Tianjin University,Tianjin,300072,China

出　　处：《Synthetic and Systems Biotechnology》2020年第2期49-58,共10页合成和系统生物技术（英文）

基　　金：This work was supported by the National Key R&D Program of China(2018YFA0903300);the Natural Science Foundation of Tianjin Province(19JCYBJC24200);the National Natural Science Foundation of China(81502966).

摘　　要：Streptomyces is an important treasure trove for natural products discovery.In recent years,many scientists focused on the genetic modification and metabolic regulation of Streptomyces to obtain diverse bioactive compounds with high yields.This review summarized the commonly used regulatory strategies for natural products discovery and overproduction in Streptomyces from three main aspects,including regulator-related strategies,promoter engineering,as well as other strategies employing transposons,signal factors,or feedback regulations.It is expected that the metabolic regulation network of Streptomyces will be elucidated more comprehensively to shed light on natural products research in the future.

关 键 词：Gene expression regulation Natural products STREPTOMYCES Biosynthetic gene clusters 

分 类 号：Q93[生物学—微生物学]