Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production  

作　　者：Bin Wang Huimin Zhao 

机构地区：[1]Carl R.Woese Institute for Genomic Biology,University of Illinois at Urbana-Champaign,Urbana,IL,USA [2]Department of Chemical and Biomolecular Engineering,University of Illinois at Urbana-Champaign,Urbana,IL,USA [3]Department of Chemistry,University of Illinois at Urbana-Champaign,Urbana,IL,USA [4]Department of Biochemistry,University of Illinois at Urbana-Champaign,Urbana,IL,USA [5]Department of Bioengineering,University of Illinois at Urbana-Champaign,Urbana,IL,USA

出　　处：《Synthetic and Systems Biotechnology》2020年第1期21-22,共2页合成和系统生物技术（英文）

基　　金：This work was supported by award AI144967(to H.Z.)from the U.S.National Institutes of Health(NIH)and awards DE-SC0018260 and DESC0018420(to H.Z.)from the U.S.Department of Energy.

摘　　要：Overproduction of polyketides has been a challenge for metabolic engineering for decades.However,recent studies have demonstrated that in both native host and heterologous host,engineeringβ-oxidation pathways can lead to dramatic improvement of polyketide production.

关 键 词：POLYKETIDE Beta-oxidation pathway Metabolic engineering Triacylglycerols 

分 类 号：Q5[生物学—生物化学]