An in vivo study on the effect of coating stability on osteointegration performance of collagen/hyaluronic acid multilayer modified titanium implants  

作　　者：Haiyong Ao Jiajia Zong Yanjiao Nie Yizao Wan Xiebin Zheng 

机构地区：[1]School of Materials Science and Engineering,East China Jiaotong University,Nanchang,330013,China [2]Key Laboratory of Inorganic Coating Materials,Shanghai Institute of Ceramics,Chinese Academy of Science,Shanghai,200050,China

出　　处：《Bioactive Materials》2018年第1期97-101,共5页生物活性材料（英文）

基　　金：This work is supported by the National Natural Science Foundation of China(Grant No.81501856).

摘　　要：Aseptic loosening of implant is one of the main causes of Ti-based implant failure.In our previous work,a novel stable collagen/hyaluronic acid(Col/HA)multilayer modified titanium coatings(TCs)was developed by layer-by-layer(LBL)covalent immobilization technique,which showed enhanced biological properties compared with TCs that were physically absorbed with Col/HA multilayer in vitro.In this study,a rabbit model with femur condyle defect was employed to compare the osteointegration performance of them.Results indicated that Col/HA multilayer with favourable stability could better facilitate osteogenesis around implants and bone-implant contact.The Col/HA multilayer covalentimmobilized TC may reduce aseptic loosening of implant.

关 键 词：Collagen I Hyaluronic acid LBL covalent immobilization STABILITY OSTEOINTEGRATION 

分 类 号：TG1[金属学及工艺—金属学]