3D printing of bone tissue engineering scaffolds  

作　　者：Chong Wang Wei Huang Yu Zhou Libing He Zhi He Ziling Chen Xiao He Shuo Tian Jiaming Liao Bingheng Lu Yen Wei Min Wang 

机构地区：[1]School of Mechanical Engineering,Dongguan University of Technology,Songshan Lake,Dongguan,Guangdong,PR China [2]Department of Orthopaedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,PR China [3]Department of Mechanical Engineering,The University of Hong Kong,Pokfulam Road,Hong Kong,Hong Kong SAR,PR China [4]Department of Chemistry,Tsinghua University,Beijing,PR China [5]Institute of Biomedical and health engineering,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong,PR China

出　　处：《Bioactive Materials》2020年第1期82-91,共10页生物活性材料（英文）

基　　金：This work was supported by Dongguan University of Technology High-level Talents(Innovation Team)Research Project(KCYCXPT201603);Youth Innovative Talent Project from the Department of Education of Guangdong Province,China(2016KQNCX168);Natural Science Foundation of Guangdong Province,China(2018A0303130019).

摘　　要：Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical outcomes.In scaffold-based bone tissue engineering,a high performance scaffold underpins the success of a bone tissue engineering strategy and a major direction in the field is to produce bone tissue engineering scaffolds with desirable shape,structural,physical,chemical and biological features for enhanced biological performance and for regenerating complex bone tissues.Three-dimensional(3D)printing can produce customized scaffolds that are highly desirable for bone tissue engineering.The enormous interest in 3D printing and 3D printed objects by the science,engineering and medical communities has led to various developments of the 3D printing technology and wide investigations of 3D printed products in many industries,including biomedical engineering,over the past decade.It is now possible to create novel bone tissue engineering scaffolds with customized shape,architecture,favorable macro-micro structure,wettability,mechanical strength and cellular responses.This article provides a concise review of recent advances in the R&D of 3D printing of bone tissue engineering scaffolds.It also presents our philosophy and research in the designing and fabrication of bone tissue engineering scaffolds through 3D printing.

关 键 词：3D printing Bone tissue engineering SCAFFOLD BIOCERAMIC POLYESTER HYDROGEL BIOMOLECULE Controlled release 

分 类 号：R318[医药卫生—生物医学工程] TP391.73[医药卫生—基础医学]