Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants  

作　　者：Teng Wan Zixue Jiao Min Guo Zongliang Wang Yizao Wan Kaili Lin Qinyi Liu Peibiao Zhang 

机构地区：[1]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,130022,PR China [2]Department of Orthopaedics,The Second Hospital,Jilin University,Changchun,130041,PR China [3]Institute of Advanced Materials,East China Jiaotong University,Nanchang,330013,PR China [4]Department of Oral&Cranio-Maxillofacial Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Stomatology,Shanghai Research Institute of Stomatology,Shanghai,200011,PR China [5]University of Science and Technology of China,Hefei,230026,PR China

出　　处：《Bioactive Materials》2020年第4期1004-1017,共14页生物活性材料（英文）

基　　金：financially supported by the National Natural Science Foundation of China(Projects.51673186 , 81672263);the Special Fund for Industrialization of Science and Technology Cooperation between Jilin Province and Chinese Academy of Sciences(2017SYHZ0021).

摘　　要：Fabricating a desired porous structure on the surface of biomedical polyetheretherketone(PEEK)implants for enhancing biological functions is crucial and difficult due to its inherent chemical inertness.In this study,a porous surface of PEEK implants was fabricated by controllable sulfonation using gaseous sulfur trioxide(SO3)for different time(5,15,30,60 and 90 min).Micro-topological structure was generated on the surface of sulfonated PEEK implants preserving original mechanical properties.The protein absorption capacity and apatite forming ability was thus improved by the morphological and elemental change with higher degree of sulfonation.In combination of the appropriate micromorphology and bioactive sulfonate components,the cell adhesion,migration,proliferation and extracellular matrix secretion were obviously enhanced by the SPEEK-15 samples which were sulfonated for 15 min.Finding from this study revealed that controllable sulfonation by gaseous SO3 would be an extraordinarily strategy for improving osseointegration of PEEK implants by adjusting the microstructure and chemical composition while maintaining excellent mechanical properties.

关 键 词：POLYETHERETHERKETONE SULFONATION Micro-topology Mechanical strength OSTEOINTEGRATION 

分 类 号：R318[医药卫生—生物医学工程]