榆叶粗提液治疗幼鼠癫痫作用初探  

A Pilot Study of the Effect of Elm Leaf Crude Extract on PTZ Induced Young Seizure Rats

作　　者：孔淑贞 程璐瑶[1,2] 曾小航 KONG Shu-zhen;CHENG Lu-yao;ZENG Xiao-hang(Key Laboratory of Natural Medicine Research of Chongqing Education Commission,College of Environment and Resources,Chongqing Technology and Business University,Chongqing 400067,China)

机构地区：[1]重庆工商大学环境与资源学院,重庆400067 [2]重庆工商大学重庆高校天然药物研究重点实验室,重庆400067

出　　处：《重庆工商大学学报（自然科学版）》2021年第1期70-77,共8页Journal of Chongqing Technology and Business University:Natural Science Edition

基　　金：国家自然科学基金(81401082);重庆市科委重点项目(CSTC2015JCYJBX0031).

摘　　要：近年来临床上越来越多采用中西医结合的方法控制癫痫疾病的发作;通过以灌胃给药的方式给予PTZ癫痫幼鼠不同浓度的榆叶粗提液,观察榆叶对PTZ幼鼠癫痫模型的癫痫行为和海马神经元的影响;结果发现:与PTZ癫痫模型组相比,高浓度榆叶粗提液干预将癫痫发生率降低了20%;榆叶粗提液中、高浓度组海马神经元数目明显增加;表明中、高浓度的榆叶粗提液对PTZ癫痫模型有一定的改善作用,一定程度上可以降低癫痫行为的发生率和抑制癫痫对海马神经元的损伤。In recent years,more and more epilepsy patients were treated with combined treatment of traditional Chinese medicine and western medicine.To observe the effect on seizure behavior and hippocampus neurons,young PTZ epilepsy rats were treated with Elm leaf crude extract by intragastric administration.The results displayed that the incidence rate of seizure reduced 20%and hippocampus neurons increased after 1.2g/kg,2.4g/kg Elm leaf extract intragastric administration.So Elm leaf extract can improve PTZ induced seizure behavior and reduce incidence of PTZ induced seizure.And Elm leaf extract can protect hippocampus neurons from damage by PTZ induced seizure.

关 键 词：榆叶 戊四唑 癫痫 海马 

分 类 号：R742.1[医药卫生—神经病学与精神病学]