Amelioration of imiquimod-induced psoriasis-like dermatitis in mice by DSW therapy inspired hydrogel  

作　　者：Xiang He Bing Zhu WeiJia Xie Yu He Jian Song Yi Zhang Chi Sun Hao Li QiYu Tang XinXin Sun Yanni Tan Yong Liu 

机构地区：[1]State Key Laboratory of Powder Metallurgy,Central South University,Changsha,410083,China [2]School of Materials Science and Engineering,Central South University,Changsha,410083,China [3]Xiangya School of Medicine,Central South University,Changsha,410083,China [4]Department of Material and Chemical Engineering,Zhengzhou University of Light Industry,Zhengzhou,450002,China [5]Department of Mechanical Engineering,Munich School of Bioengineering,Technical University of Munich,85748,Garching,Germany [6]Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,130022,China [7]Center for Medical Genetics,Hunan Key Laboratory of Medical Genetics,School of Life Sciences,Central South University,Changsha,410083,China [8]A.James Clark School of Engineering,University of Maryland,College Park,20742,MD,United States

出　　处：《Bioactive Materials》2021年第2期299-311,共13页生物活性材料（英文）

基　　金：The authors would like to thank the financial support by National Natural Science Funds for Distinguished Young Scholar of China(51625404);China Scholarship Council(202006370330);State Key Laboratory of Powder Metallurgy,Central South University,Changsha,China.

摘　　要：Psoriasis is a long-lasting and recurrent autoimmune disease which is incurable so far.Dead Sea water(DSW)therapy is an effective approach to help control the symptoms of psoriasis due to the abundant mineral ions in DSW,which inspired the material formulation in this study.Rubidium–Sodium alginate/Polyacrylamide hydrogels(Rb-SA/PAAm gels)composed of sodium alginate and polyacrylamide interpenetrating network structure with different concentrations of rubidium and certain magnesium and zinc content were prepared for the treatment of psoriasis.The obtained results suggest the good mechanical properties of the Rb-SA/PAAm gels including toughness and swelling performance.In terms of in vitro tests,the Rb-SA/PAAm gels not only show nontoxicity to human keratinocyte cell line(Hacats)but also inhibits the activity against inflammatory NF-κβ signaling pathway.Meanwhile,they can release Rb+which enable the Rb-SA/PAAm gels have better antibacterial ability to Streptococcus and Escherichia coli.The results obtained from in vivo tests indicate that these hydrogels could alleviate the symptoms of psoriasis caused by Imiquimod(IMQ)in mice by reducing the inflammatory factor in STAT3 pathway and therefore reduce the immune stimulation of the spleen.In conclusion,the 100Rb-SA/PAAm gel has demonstrated great potential to be a topical wettable dressing for psoriasis treatment.

关 键 词：DSW therapy RUBIDIUM Hydrogels IMIQUIMOD Psoriasis 

分 类 号：R318[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]