鼠神经生长因子联合强的松治疗对老年急性前庭神经炎患者前庭功能和氧化应激水平的影响  

Effect of mouse nervous growth factor combined with prednisone on vestibular function and oxidative stress level in elderly patients with acute vestibular neuritis

作　　者：杨云鹏[1] 张爱香[1] 任蓓[1] 王静[1] YANG Yun-peng;ZHANG Ai-xiang;REN Bei;WANG Jing(Department of Neurology,the Fourth Hospital of Xi'an City,Xi'an 710004,Shaanxi,CHINA)

机构地区：[1]西安市第四医院神经内科,陕西西安710004

出　　处：《海南医学》2021年第2期160-164,共5页Hainan Medical Journal

摘　　要：目的探讨鼠神经生长因子与强的松联合应用对老年急性前庭神经炎(AVN)患者前庭功能及氧化应激水平的影响。方法选取2018年1月至2019年12月西安市第四医院收治的老年AVN患者112例进行前瞻性随机对照研究,以随机数表法分为联合组和对照组,每组56例。对照组患者给予强的松治疗,联合组患者则给予鼠神经生长因子联合强的松治疗,均治疗两周。比较两组的临床疗效、不良反应,以及治疗前后的眩晕残障程度评定量表(DHI)评分、自发性眼震角度、半规管轻瘫值、日常活动前庭功能障碍等级量表(VADL)评分、血清炎症因子指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]水平。结果联合组患者的治疗总有效率为89.29%,明显高于对照组的73.21%,差异有统计学意义(P<0.05);联合组和对照组患者的不良反应发生率分别为7.14%、5.36%,差异无统计学意义(P>0.05);治疗两周后,两组患者的DHI评分、VADL评分较治疗前降低,联合组分别为(6.49±3.13)分、(1.81±0.47)分,明显低于对照组的(11.40±3.62)分、(3.20±0.65)分,差异均有统计学意义(P<0.05);两组患者治疗2周后的自发性眼震角度、半规管轻瘫值均明显改善,联合组分别为(0.52±0.17)°、(53.75±8.62)%,明显优于对照组的(0.96±0.25)°、(61.36±9.41)%,差异均有统计学意义(P<0.05);治疗两周后,联合组患者的血清TNF-α、IL-6、SOD、MDA水平分别为(14.42±1.06)pg/L、(14.30±1.58)pg/mL、(68.42±7.65)U/mL、(3.98±0.36)nmol/mL,明显优于对照组的(15.26±1.29)pg/mL、(15.14±1.83)pg/mL、(65.18±7.34)U/mL、(4.31±0.45)nmol/mL,差异均有统计学意义(P<0.05)。结论鼠神经生长因子联合强的松治疗老年AVN可有效减轻患者眩晕程度,调节机体炎症及氧化应激水平,改善前庭功能,缓解眼震及半规管轻瘫状态,临床疗效显著且安全性较好。Objective To investigate the effect of combined application of mouse nervous growth factor and prednisone on vestibular function and oxidative stress in elderly patients with acute vestibular neuritis(AVN).Methods From January 2018 to December 2019,112 elderly AVN patients in the Fourth Hospital of Xi'an City were selected for a prospective randomized controlled study.They were divided into a combined group and a control group based on a random number table,each with 56 cases.Patients in the control group were treated with prednisone,and patients in the combined group were treated with mouse nervous growth factor combined with prednisone,both for 2 weeks.The clinical efficacy,adverse reactions,and Dizziness Handicap Inventory(DHI)scores,spontaneous nystagmus angle,paraplegia value of semicircular canal,and vestibular disorders activities of daily living scale(VADL)score,serum inflammatory factor indexes(tumor necrosis factor-α[TNF-α],interleukin-6[IL-6]),oxidative stress indicators(superoxide dismutase[SOD],malondialdehyde[MDA])levels before and after treatment were compared between the two groups.Results The total effective rate of treatment in the combined group was 89.29%,which was significantly higher than 73.21%in the control group(P<0.05).The incidence of adverse reactions in the combined group and control group were 7.14%and 5.36%,respectively,and there was no statistically significant difference(P>0.05).After 2 weeks of treatment,the DHI score and VADL score of the two groups were lower than those before treatment;the scores of the combined group were(6.49±3.13)points and(1.81±0.47)points,respectively,which were significantly lower than(11.40±3.62)points and(3.20±0.65)points of the control group(P<0.05).The angle of spontaneous nystagmus and the value of semicircular canal paresis of the two groups were significantly improved after 2 weeks of treatment;the two indexes were(0.52±0.17)°and(53.75±8.62)%,which were significantly better than(0.96±0.25)°and(61.36±9.41)%of the control group(P<0.05).A

关 键 词：老年 急性前庭神经炎 鼠神经生长因子 强的松 前庭功能 炎症因子 氧化应激 安全性 

分 类 号：R745[医药卫生—神经病学与精神病学]