环状RNA与脑血管疾病关系的研究进展  

Research progress of the relationship between circRNA and cerebrovascular diseases

作　　者：付雪雯(综述) 余素(审校) 周敬华(审校)[1] FU Xue-wen;YU Su;ZHOU Jing-hua(Department of Neurology,Yichang Central People's Hospital,the First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,Hubei,CHINA)

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院神经内科,湖北宜昌443003

出　　处：《海南医学》2021年第2期236-239,共4页Hainan Medical Journal

摘　　要：环状RNA是真核生物中具有组织特异性和细胞特异性的共价封闭内源性生物分子,其生物特性受特定顺式作用元件和反式作用因子的调控。circRNAs和miRNA在竞争性内源RNA中结合能力最强,在细胞基因表达中起着miRNA分子海绵功能,并通过调控蛋白的翻译与表达等途径来调节多种疾病。circRNAs通过调控血管内皮细胞、血管平滑肌胞、血压等对脑血管病发生和发展产生重要作用。为了解circRNAs及其在调节脑血管疾病分子机制方面的研究进展,寻找潜在的药物分子标志物,本文对circRNAs在脑血管疾病进展中的研究进行简要概述,以寻求脑血管病诊疗新思路。circRNA is a covalently enclosed endogenous biomolecule with tissue and cell specificity in eukaryotes.Its biological characteristics are regulated by specific cis-regulatory elements and trans-acting factors.circRNAs and miRNA have the strongest binding ability in competitive endogenous RNA,and play the role of miRNA molecular sponge in cell gene expression,and regulate a variety of diseases by regulating protein translation and expression.circRNAs play an important role in the occurrence and development of cerebrovascular diseases by regulating vascular endothelial cells,vascular smooth muscle cells and blood pressure.In order to systematically understand the research progress of circRNAs and its molecular mechanism in the regulation of cerebrovascular diseases,and to search for potential drug molecular markers,this paper briefly summarizes the research of circRNAs in the progress of cerebrovascular diseases,so as to seek new ideas for the diagnosis and treatment of cerebrovascular diseases.

关 键 词：环状RNA 真核生物 竞争性内源RNA MIRNA 分子海绵 脑血管病 

分 类 号：R743[医药卫生—神经病学与精神病学]