奈达铂联合5-氟尿嘧啶治疗晚期食管癌患者的临床效果  

Clinical Efficacy of Nedaplatin Combined with 5-fluorouracil in the Treatment of Advanced Esophageal Cancer

作　　者：孙相辉[1] SUN Xianghui(Department of Oncology,Enliang Hospital in Tai'an County,Anshan 114100,China)

机构地区：[1]鞍山市台安县恩良医院肿瘤科,辽宁鞍山114100

出　　处：《中国医药指南》2020年第36期107-108,共2页Guide of China Medicine

摘　　要：目的分析奈达铂联合5-氟尿嘧啶治疗晚期食管癌患者的临床效果及安全性。方法选择我科2015年1月至2018年12月收治的74例晚期食管癌患者作为研究对象,按照随机原则分为观察组和对照组,每组37例。观察组患者给予奈达铂联合5-氟尿嘧啶治疗,对照组患者给予顺铂联合5-氟尿嘧啶治疗,观察两组患者的临床疗效及不良反应发生率。结果观察组患者的临床总有效率显著高于对照组(P<0.05);观察组患者骨髓造血功能障碍、胃肠道反应、肝肾功能损害及脱发等不良反应发生率均低于对照组患者(P<0.05)。结论奈达铂相比于顺铂具有更高的溶出度,能更有效的抑制食管癌细胞DNA的复制,降低癌细胞的扩散速度,缓解患者的临床症状,改善其预后。Objective To study and analyze the clinical efficacy and safety of nedaplatin combined with 5-fluorouracil in the treatment of advanced esophageal cancer.Methods A total of 74 patients with advanced esophageal cancer who were admitted to our department from January 2015 to December 2018 were selected as the study subjects.They were randomly divided into two groups,37 cases in each group.Patients in the observation group were treated with nedaplatin combined with 5-fluorouracil,while patients in the control group were treated with cisplatin combined with 5-fluorouracil.The clinical efficacy and incidence of adverse reactions of the two groups were observed.Results The total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05);the incidence of adverse reactions such as hematopoietic dysfunction,gastrointestinal reactions,liver and kidney dysfunction and alopecia were lower in the observation group than in the control group(P<0.05).Conclusion Compared with cisplatin,nedaplatin has a higher dissolution rate,can more effectively inhibit the DNA replication of esophageal cancer cells,reduce the spread of cancer cells,alleviate the clinical symptoms of patients,and improve their prognosis.

关 键 词：晚期食管癌 奈达铂 5-氟尿嘧啶 化学治疗 预后 

分 类 号：R735.1[医药卫生—肿瘤]