奥曲肽、垂体后叶素治疗肝硬化上消化道出血的临床观察  

Clinical Observation of Octreotide and Pituitrin in the Treatment of Liver Cirrhosis with Upper Gastrointestinal Bleeding

作　　者：吕东 LV Dong(Department of Internal Medicine,Beizhen People's Hospital,Jinzhou 121300,China)

机构地区：[1]辽宁省锦州市北镇市人民医院内科,辽宁锦州121300

出　　处：《中国医药指南》2020年第36期119-120,共2页Guide of China Medicine

摘　　要：目的观察奥曲肽、垂体后叶素治疗肝硬化上消化道出血的临床效果。方法选取收治的82例肝硬化上消化道出血患者,根据不同治疗方案将其分成两组,每组41例。对照组采用垂体后叶素(6 U,静脉注射,再以垂体后叶素36 U+5%葡萄糖溶液500 mL,静脉滴注,滴速3~5 mL/min)治疗,观察组采用奥曲肽(0.1 mg,配以生理盐水20 mL,静脉注射,再以25~50μg/h的速度持续静脉滴注)治疗。比较两组的临床疗效和不良反应发生情况,记录患者止血时间和住院时间。结果观察组患者的止血时间(20.68±7.29)h和住院时间(14.64±3.62)d明显短于对照组的(32.97±11.14)h和(19.29±6.38)d(P<0.05);观察组的治疗有效率(92.68%)明显高于对照组(75.61%)(P<0.05);观察组不良反应发生率(4.88%)明显低于对照组(21.95%)(P<0.05)。结论与垂体后叶素相比,奥曲肽治疗肝硬化上消化道出血能够有效缩短患者止血时间,提升疗效,减少不良反应,促进患者早日康复出院。Objective Observe the clinical effects of octreotide and pituitrin on upper gastrointestinal bleeding in liver cirrhosis.Methods A total of 82 patients with upper gastrointestinal bleeding from liver cirrhosis were selected and divided into two groups according to different treatment plans,with 41 cases in each group.The control group was treated with pituitrin(6 U,intravenous injection,followed by 500 mL of pituitrin 36 U+5%glucose solution,intravenous drip,drip rate 3-5 mL/min),and the observation group was treated with octreotide(0.1 mg,with 20 mL of normal saline,intravenous injection,and then continuous intravenous drip at a rate of 25-50μg/h)treatment.Compare the clinical efficacy and adverse reactions between the two groups,and record the patient's hemostasis time and hospitalization time.Result The hemostatic time(20.68±7.29)h and hospitalization time(14.64±3.62)d of the observation group were significantly shorter than those of the control group(32.97±11.14)h and(19.29±6.38)d(P<0.05);treatment of the observation group the effective rate(92.68%)was significantly higher than that of the control group(75.61%)(P<0.05);the incidence of adverse reactions in the observation group(4.88%)was significantly lower than that of the control group(21.95%)(P<0.05).Conclusion Compared with pituitrin,octreotide in the treatment of upper gastrointestinal bleeding in liver cirrhosis can effectively shorten the time of hemostasis,improve the efficacy,reduce adverse reactions,and promote the patient's early recovery and discharge.

关 键 词：上消化道出血 肝硬化 奥曲肽 垂体后叶素 止血 

分 类 号：R573.2[医药卫生—消化系统] R575.2[医药卫生—内科学]