Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation  

作　　者：Ilham Touiss Saloua Khatib Oussama Bekkouch Souliman Amrani Hicham Harnafi 

机构地区：[1]Laboratory of Biochemistry and Biotechnologies,Department of Biology,Faculty of Sciences,60000 Oujda,Morocco

出　　处：《Food Science and Human Wellness》2017年第1期28-33,共6页食品科学与人类健康（英文）

摘　　要：In this study we investigated the hypolipidemic and anti-lipoprotein-oxidation activities of phenolic extract from sweet basil a popular culinary herb.The hypolipidemic activity was studied in mice model injected intraperitoneally with Triton WR-1339 at a dose of 200 mg/kg body weight.The animals were grouped as follows:normolipidemic control group(n=8),hyperlipidemic control group(n=8)and phenolic extract-treated group(n=8)at a dose of 200 mg/kg body weight.After 7 h and 24 h treatment,the oral administration of the phenolic extract exerts a significant reduction of plasma total cholesterol,triglycerides and LDL-cholesterol concentrations(P<0.001).On the other hand,we demonstrated that the phenolic extract prevents plasma lipid oxidation by 16%(P<0.001),20%(P<0.001),32%(P<0.001)and 44%(P<0.001)at a doses of 10,25,50 and 100g/mL,respectively.The results were compared with ascorbic acid used as standard synthetic antioxidant.HPLC analysis shows that the extract contains 4 major phenolics and is especially rich in rosmarinic acid.This finding indicates that the phenolic extract might be beneficial in lowering hyperlipidemia and preventing atherosclerosis.

关 键 词：Sweet basil Phenolic acids Hypocholesterolaemia Hypotriglyceridaemia Lipoprotein-rich plasma oxidation 

分 类 号：TS201.4[轻工技术与工程—食品科学]