Simple glycolipids of microbes:Chemistry,biological activity and metabolic engineering  

作　　者：Ahmad Mohammad Abdel-Mawgoud Gregory Stephanopoulos 

机构地区：[1]Department of Chemical Engineering,Massachusetts Institute of Technology,77 Massachusetts Ave.,Cambridge,MA 02139,USA

出　　处：《Synthetic and Systems Biotechnology》2018年第1期3-19,共17页合成和系统生物技术（英文）

基　　金：This work was funded by the United States Department of Energy-Chicago(DoE-Chicago)grant DE-SC0008744 to Professor Gregory Stephanopoulos;Dr.Ahmad M.Abdel-Mawgoud is funded by a postdoctoral fellowship from the Natural Sciences and Engineering Research Council of Canada(NSERC),funding reference number PDF-488195-2016,and partly by the US DoE grant DESC0008744 mentioned above。

摘　　要：Glycosylated lipids(GLs)are added-value lipid derivatives of great potential.Besides their interesting surface activities that qualify many of them to act as excellent ecological detergents,they have diverse biological activities with promising biomedical and cosmeceutical applications.Glycolipids,especially those of microbial origin,have interesting antimicrobial,anticancer,antiparasitic as well as immunomodulatory activities.Nonetheless,GLs are hardly accessing the market because of their high cost of production.We believe that experience of metabolic engineering(ME)of microbial lipids for biofuel production can now be harnessed towards a successful synthesis of microbial GLs for biomedical and other applications.This review presents chemical groups of bacterial and fungal GLs,their biological activities,their general biosynthetic pathways and an insight on ME strategies for their production.

关 键 词：BIOSURFACTANT Glycolipids biosynthesis Glycosyl/acyl transferases GLYCOSIDES Physiological roles Lipid biotechnology 

分 类 号：O62[理学—有机化学]