立体定向放射外科治疗联合免疫检测点抑制剂在脑转移瘤中的应用  

Application of stereotactic radiosurgery combined with immune checkpoint inhibitors in brain metastasis

作　　者：邓义飞 苏州[1] 薛建新 DENG Yifei;SU Zhou;XUE Jianxin(Department of Thoracic Oncology,Cancer Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China;Department of Radiation Oncology,Chengdu Seventh People’s Hospital,Chengdu,Sichuan 610041,P.R.China)

机构地区：[1]四川大学华西医院肿瘤中心胸部肿瘤科,成都610041 [2]成都市第七人民医院放疗科,成都610041

出　　处：《华西医学》2021年第1期125-130,共6页West China Medical Journal

基　　金：国家自然科学基金(81872478)。

摘　　要：脑转移瘤是成年人最常见的颅内恶性肿瘤,放射治疗是脑转移瘤常用的治疗手段之一,特别是立体定向放射外科治疗能很好地控制肿瘤,且较全脑放射治疗能显著减少对认知功能的影响。而免疫检测点抑制剂在多种晚期肿瘤患者治疗中毒副反应较小,且显示出良好的生存优势。该文介绍了脑转移瘤的放射治疗、免疫治疗、立体定向放射外科治疗联合免疫检测点抑制剂,探讨了立体定向放射外科治疗联合免疫检测点抑制剂的作用机制,及其在脑转移瘤中的治疗价值和研究进展,旨在为立体定向放射外科治疗联合免疫检测点抑制剂更好地应用于脑转移瘤提供理论基础。Brain metastases are the most common intracranial malignant tumors in adults.Radiotherapy is a common treatment for brain metastases.In particular,stereotactic radiosurgery can control tumors well,and can significantly reduce the impact on cognitive function compared with whole brain radiation therapy.Immune checkpoint inhibitors have less toxic side effects in the treatment of patients with advanced tumors,and show good survival advantages.This article introduces radiotherapy,immunotherapy,stereotactic radiosurgery combined with immune checkpoint inhibitors for brain metastases,discusses the mechanism of stereotactic radiosurgery combined with immune checkpoint inhibitors,and its therapeutic value and research progress in brain metastases,aiming to provide a theoretical basis for the better application of stereotactic radiosurgery combined with immune checkpoint inhibitors to brain metastases.

关 键 词：立体定向放射外科治疗 免疫治疗 免疫检测点抑制剂 脑转移瘤 

分 类 号：R739.41[医药卫生—肿瘤] R730.55[医药卫生—临床医学]