胸部CT和肿瘤标志物检测对肺癌早期筛查的临床价值研究  

Study on the clinical value of chest CT and tumor markers in the early screening of lung cancer

作　　者：瞿红英 张玲[1] 王淑贤[1] QU Hong-ying;ZHANG Ling;WANG Shu-xian(Physical examination Department,First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology,Baotou 014010,China)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院体检科,014010

出　　处：《中国实用医药》2021年第1期34-36,共3页China Practical Medicine

摘　　要：目的探讨在肺癌早期筛查中采取胸部CT以及肿瘤标志物检测的诊断价值。方法选取68例行胸部检查且确诊为肺癌的患者作为肺癌组,另选取同期68例体检健康者作为健康组。所有患者先进行DR胸部正位摄片检查再给予胸部CT平扫扫描。比较DR检查与胸部CT检查的肺癌检出率以及两组肿瘤标志物[癌胚抗原(CEA)、糖类抗原211(CA211)、神经元特异性烯醇化酶(NSE)]水平。结果胸部CT检查肺癌检出率97.1%高于DR检测的83.8%,差异具有统计学意义(P<0.05)。肺癌组患者CEA、CA211、NSE水平分别为(8.33±2.75)、(2.04±1.78)、(10.62±2.11)ng/ml,均高于健康组的(2.85±1.32)、(1.32±0.68)、(8.52±2.08)ng/ml,差异均具有统计学意义(P<0.05)。结论采取胸部CT以及肿瘤标志物的检测可有效对肺癌早期患者进行筛查,尽早治疗以改善肺癌患者的预后,提高生存率,能够作为临床诊断的重要依据。Objective To discuss the clinical value of chest CT and tumor markers in the early screening of lung cancer.Methods There were 68 patients with lung cancer diagnosed by chest examination selected as the lung cancer group,and 68 healthy people in the same period as the healthy group.All patients underwent DR chest radiography and then chest CT scan.Comparison was made on the detection rate of lung cancer in DR and chest CT and the levels of tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 211(CA211),neuron-specific enolase(NSE)]between the two groups.Results The detection rate of lung cancer in chest CT 97.1%was higher than 83.8%in DR,and the difference was statistically significant(P<0.05).The levels of CEA,CA211 and NSE of lung cancer patients were(8.33±2.75),(2.04±1.78)and(10.62±2.11)ng/ml,which were all higher than(2.85±1.32),(1.32±0.68)and(8.52±2.08)ng/ml of healthy group,and the difference was statistically significant(P<0.05).Conclusion Chest CT and tumor markers detection can effectively screen patients with early lung cancer,and treat them as soon as possible to improve the prognosis of lung cancer patients and increase survival rate,which can be used as an important basis for clinical diagnosis.

关 键 词：肺癌 早期筛查 胸部CT 肿瘤标志物 检出率 

分 类 号：R734.2[医药卫生—肿瘤]