慢性乙型肝炎病毒感染与成人糖尿病患病的关联研究  

Association between chronic hepatitis B virus infection and diabetes among adults

作　　者：王浩[1] 陈玲琍 谢开婿[2] 王春梅[2] 曹元[2] 沈盾 张晓怡[2] 祝水清 胡如英[1] 卞铮[3] 郭彧[3] 俞敏[1] 陈铮鸣[4] 李立明[5] WANG Hao;CHEN Lingli;XIE Kaixu;WANG Chunm ei;CAO Yuan;SHEN Dun;ZHANG Xiaoyi;ZHU Shuiqing;HU Ruying;BIAN Zheng;GUO Yu;YU Min;CHEN Zhengming;LI Liming(Department of Non-com municable Diseases Control and Prevention,Zhejiang Provincial Center for Diseases Control and Prevention,Zhejiang,Hangzhou 310051,China)

机构地区：[1]浙江省疾病预防控制中心慢性非传染性疾病防制所,浙江杭州310051 [2]桐乡市疾病预防控制中心 [3]中国医学科学院 [4]英国牛津大学临床与流行病学研究中心 [5]北京大学公共卫生学院

出　　处：《预防医学》2021年第1期1-5,共5页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：国家重点研发计划精准医学研究重点专项(2016YFC0900500,2016YFC0900501,2016YFC0900502,2016YFC0900504);香港Kadoorie Charitable基金;英国Wellcome Trust(202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z)。

摘　　要：目的分析慢性乙型肝炎病毒感染与成人糖尿病患病的关联。方法基于中国慢性病前瞻性研究项目,对2004年8月―2008年5月浙江省桐乡市社区居民进行问卷调查、体格检查和实验室检测。采用Logistic回归模型分析慢性乙型肝炎病毒感染与成年人糖尿病患病的关联。结果共纳入52 888人,HBsAg阳性1 877例,阳性率为3.55%。糖尿病患者2 733例,患病率为5.17%。糖尿病患者中HBsAg阳性96例,阳性率为3.51%。单因素和多因素Logistic回归分析结果均显示,糖尿病患病与HBsAg未见统计学关联(P>0.05)。结论慢性乙型肝炎病毒感染与成人糖尿病患病未见统计学关联。Objective To explore the association between chronic hepatitis B virus infection and diabetes among adults.Methods The baseline data of China Kadoorie Biobank(CKB)study from Tongxiang of Zhejiang Province was used for analysis.Community residents were investigated in the study from August 2004 to May 2008,including questionnaire survey,physical measurement and biological sample test.Univariate and multivariate logistic regression models were used to estimate the association of chronic hepatitis B virus infection with diabetes.Results Totally 52888 participants were included in the final analysis.The overall prevalence of HBsAg-positive was 3.55%(N=1877).The overall prevalence of diabetes was 5.17%(N=2733).The prevalence of HBsAg-positive in diabetic patients was 3.51%(N=96).Both univariate and multivariate logistic regression models indicated that there was no association between chronic hepatitis B virus infection and diabetes(P>0.05).Conclusion No significant association has been found between chronic hepatitis B virus infection and diabetes among adults.

关 键 词：糖尿病 乙型肝炎病毒 横断面研究 

分 类 号：R[医药卫生]