竞争性内源RNA在支气管哮喘中的研究进展  

Research progress of competing endogenous RNA in bronchial asthma

作　　者：何山川 钱粉红[1] HE Shanchuan;QIAN Fenhong(Department of Respiratory and Critical Care Medicine,the Afliated Hospital of Jiangsu University,Zhenjiang 212000,China)

机构地区：[1]江苏大学附属医院呼吸与危重症医学科,江苏镇江212000

出　　处：《中国比较医学杂志》2021年第1期113-119,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金项目(81370119);镇江市科技支撑计划(SH2015044)。

摘　　要：支气管哮喘是一种以气道炎症、气道高反应性和气道重塑为特征的慢性气道疾病,常表现为反复的喘息、咳嗽和胸闷。近期许多研究表明,lncRNA和circRNA可通过与microRNA应答元件与靶miRNA分子发生相互作用,形成竞争性内源RNA调控网络,参与转录后水平基因表达的调控,影响哮喘发生发展过程。本文就ceRNA调控机制及其对哮喘的影响进行综述。Bronchial asthma is a chronic inflammatory disease characterized by airway inflammation,hyperresponsiveness,and remodeling,which are manifested as recurrent wheezing or coughing and chest distress.Recent studies indicate that lncRNAs and circRNAs competitively sponge miRNAs via microRNA response elements,form a competing endogenous RNA regulatory network,and therefore regulate post-transcriptional gene expression and play a major regulating role in the development and progression of asthma.This article reviews the mechanisms of ce RNA and its effects on asthma.

关 键 词：哮喘 竞争性内源RNA 长链非编码RNA 微小RNA 环状RNA 

分 类 号：R-33[医药卫生]