PDX模型在胃癌研究方面的应用与挑战  

Application and challenges of a patient-derived xenograft model in the study of gastric cancer

作　　者：李雨真 金春晖[1] LI Yuzhen;JIN Chunhui(Wuxi Hospital afiliated to Nanjing University of Chinese Medicine,Department of Oncology,Wuxi 214071,China)

机构地区：[1]南京中医药大学附属无锡医院肿瘤科,江苏无锡214071

出　　处：《中国比较医学杂志》2021年第1期146-150,共5页Chinese Journal of Comparative Medicine

基　　金：无锡市卫健委精准医学专项项目(J201801)。

摘　　要：在我国,胃癌发病率随着人口老龄化的越来越严重将成上升趋势,而它又是死亡率较高的恶性肿瘤。现如今,缺乏有效的抗肿瘤药物是关键因素,故临床前研究至关重要,动物模型与其密切相关。现代研究强调肿瘤的精准治疗,于是人源性异种移植模型(patient-derived xenograft,PDX)应运而生,它与病人原始肿瘤的生物特征有很高的一致性,弥补了传统细胞系模型的不足,为肿瘤研究提供了新的平台选择。本文综述了胃癌PDX模型的建立方法,归纳了近几年来的研究应用,提出了建立胃癌PDX模型的挑战。In China,the incidence of gastric cancer has increased with the aging population,and this is a malignant cancer with high mortality.Currently,the lack of effective anti-tumor drugs is a key concern;therefore,preclinical research is crucial,and animal models are important.Modern research emphasizes precise tumor treatment,and patient-derived xenografts(PDX)have emerged from related research.PDX are highly consistent with the biological characteristics of the original tumor,which addresses the deficiencies of the traditional cell line model and provides a new platform for tumor research.In this paper,we review the established method of PDX modelling for gastric cancer.We also summarize the related research and its application in recent years.

关 键 词：胃癌 PDX模型 综述 

分 类 号：R-33[医药卫生]