美金刚联合脑电磁治疗阿尔茨海默病痴呆的行为精神症状的疗效观察  

Memantine combined with brain electromagnetic therapy in the treatment of Alzheimer's disease with behavioral and psychological symptoms of dementia

作　　者：冯丽[1] 来芹美[1] 胡琳[1] 施铁英[1] 姜龙[1] Li Feng;Qin-mei Lai;Lin Hu;Tie-ying Shi;Long Jiang(Department of Cadres Healthcare,Wangjiangshan Campus,Zhejiang Provincial People's Hospital(People's Hospital of Hangzhou Medical College),Hangzhou,Zhejiang 310014,China)

机构地区：[1]浙江省人民医院(杭州医学院附属人民医院)望江山院区干部科,浙江杭州310014

出　　处：《中国现代医学杂志》2021年第2期77-81,共5页China Journal of Modern Medicine

基　　金：2019浙江省医药卫生科技计划面上项目(No:2019KY306)。

摘　　要：目的探讨美金刚联合脑电磁治疗阿尔茨海默病(AD)痴呆的行为精神症状(BPSD)的研究。方法选取2017年1月—2020年1月在浙江省人民医院就诊的AD伴BPSD患者122例,按照随机表法分为观察组和对照组,各61例。对照组口服美金刚片;观察组在对照组基础上结合脑电磁治疗。两组疗程均为12周。比较两组疗效,以及治疗前后简易精神状态检查(MMSE)、日常生活活动(ADL)、AD病理行为症状量表(BEHAVE-AD)、神经精神量表(NPI)评分及脑源性神经营养因子(BDNF)、多巴胺(DA)、5-羟色胺(5-HT)水平变化。结果观察组治疗后总有效率高于对照组(P<0.05)。观察组治疗前后MMSE评分、ADL评分、BEHAVE-AD评分、NPI总分和NPI苦恼因子评分的差值高于对照组(P<0.05)。观察组治疗前后血清BDNF、DA和5-HT水平的差值高于对照组(P<0.05)。结论美金刚联合脑电磁治疗AD患者BPSD临床疗效较好,值得临床借鉴。Objective To investigate the effect of memantine combined with brain electromagnetic therapy on Alzheimer's disease(AD)with behavioral and psychological symptoms of dementia(BPSD).Methods The 122 patients with AD and BPSD in Zhejiang Provincial People's Hospital from January 2017 to January 2020 were randomly divided into observation group(61 cases)and control group(61 cases).The control group was treated with memantine tablets,while the observation group was treated with brain electromagnetic therapy on the basis of memantine.The course of treatment was 12 weeks in both groups.Before and after treatment,Mini-Mental State Examination(MMSE)score,Activities of Daily Living(ADL)score,Behavioral Pathology in Alzheimer's Disease(BEHAVE-AD)score,Neuropsychiatric Inventory(NPI)score,brain-derived neurotrophic factor(BDNF),dopamine(DA)and 5-hydroxytryptamine(5-HT)levels were compared between the two groups.Results After treatment,the overall effective rate in the observation group was higher than that in control group(P<0.05).The differences of MMSE score,ADL score,BEHAVE-AD score,total NPI score and the score of caregivers'distress before and after treatment in the observation group were higher than those in control group(P<0.05).The differences of serum BDNF, DA and 5-HT levels before and after the treatment in the observation group were higherthan those in the control group (P < 0.05). Conclusions Memantine combined with brain electromagnetic therapyfor AD patients with BPSD shows great clinical efficacy, which is worthy of clinical reference.

关 键 词：阿尔茨海默病 精神分析 美金刚 脑电磁 治疗 临床研究性 

分 类 号：R749.16[医药卫生—神经病学与精神病学]