神经节苷脂联合复方左旋多巴治疗帕金森病的效果  

The Effect of Ganglioside Combined with Benserazide in the Treatment of Parkinson's Disease

作　　者：许红玉 梅育嘉[2] 罗杰峰[2] XU Hong-yu;MEI Yu-jia;LUO Jie-feng(Department of Neurology,Minzu Hospital of Guangxi Zhuang Autonomous Region,Nanning 530001,Guangxi,China;Department of Neurology,the Second Affiliated Hospital of Guangxi Medical University,Nanning 530007,Guangxi,China)

机构地区：[1]广西民族医院神经内科,广西南宁530001 [2]广西医科大学第二附属医院神经内科,广西南宁530007

出　　处：《医学信息》2021年第3期160-161,共2页Journal of Medical Information

摘　　要：目的探讨神经节苷脂联合复方左旋多巴治疗帕金森病的效果。方法选择2017年1月~2019年12月我院接受治疗的262例帕金森病患者作为研究对象,按照随机数表法分为观察组与对照组,每组131例。对照组给予复方左旋多巴治疗,观察组在对照组基础上联合神经节苷脂治疗,比较两组治疗前后认知功能与氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)]变化。结果治疗4周后,观察组MoCA评分高于对照组[(88.36±3.69)分vs(75.68±2.21)分],差异有统计学意义(P<0.05);观察组MDA水平低于对照组,SOD、GSH水平高于对照组,差异有统计学意义(P<0.05)。结论神经节苷脂联合复方左旋多巴治疗帕金森病患者,可有效改善患者认知功能,减轻氧化应激反应。Objective To investigate the effect of ganglioside combined with Benserazide in the treatment of Parkinson's disease.Methods A total of 262 Parkinson's disease patients who were treated in our hospital from January 2017 to December 2019 were selected as the research objects.They were divided into observation group and control group according to the random number table method,with 131 cases in each group.The control group was given Benserazide treatment,and the observation group was combined with ganglioside treatment on the basis of the control group.The cognitive function and oxidative stress indexes[malondialdehyde(MDA),superoxide dismutase(SOD),glutathione(GSH)]changes.Results After 4 weeks of treatment,the MoCA score of the observation group was higher than that of the control group[(88.36±3.69)points vs(75.68±2.21)points],the difference was statistically significant(P<0.05);The MDA level of the observation group was lower than that of the control group,and the levels of SOD and GSH were higher than the control group,the difference was statistically significant(P<0.05).Conclusion Ganglioside combined with Benserazide in the treatment of patients with Parkinson's disease can effectively improve patients'cognitive function and reduce oxidative stress.

关 键 词：帕金森病 复方左旋多巴 神经节苷脂 认知功能 氧化应激指标 

分 类 号：R742.5[医药卫生—神经病学与精神病学]