间苯三酚和山莨菪碱在ERCP术后胰腺炎预防中的应用效果比较  

Comparison of the application effects of phloroglucinol and anisodamine in the prevention of pancreatitis after endoscopic retrograde cholangiopancreatography

作　　者：陈明会[1] 齐武强 薛梅苓 CHEN Minghui;QI Wuqiang;XUE Meiling(HanzhongPeople's Hospital,Hanzhong 723000;Baoji Hospital of Traditional Chinese Medicine,Baoji 721000;521 Hospital of Norinco Grop,Xi'an 710065,China)

机构地区：[1]汉中市人民医院,陕西汉中723000 [2]宝鸡市中医院,陕西宝鸡721000 [3]西安•兵器工业521医院,陕西西安710065

出　　处：《临床医学研究与实践》2021年第3期67-69,共3页Clinical Research and Practice

摘　　要：目的比较间苯三酚和山莨菪碱在经内镜逆行胰胆管造影术(ERCP)术后胰腺炎预防中的应用效果。方法选取2017年12月至2019年12月我院收治的84例行ERCP术患者,随机将其分为间苯三酚组(ERCP术前给予间苯三酚注射液)和山莨菪碱组(ERCP术前给予山莨菪碱注射液),每组42例。比较两组的临床效果。结果间苯三酚组的手术时间、腹痛持续时间短于山莨菪碱组,胰腺炎发生率低于山莨菪碱组(P<0.05)。治疗后,两组淀粉酶和CRP水平较治疗前升高,但间苯三酚组低于山莨菪碱组(P<0.05)。间苯三酚组的血压偏高、排尿困难发生率低于山莨菪碱组(P<0.05);两组心悸、恶心呕吐发生率比较,差异不具有统计学意义(P>0.05)。结论与山莨菪碱相比,间苯三酚在ERCP术后胰腺炎预防中的应用效果更佳,其可有效改善患者的淀粉酶及CRP水平,且不良反应少,安全可靠。Objective To compare the application effects of phloroglucinol and anisodamine in the prevention of pancreatitis after endoscopic retrograde cholangiopancreatography(ERCP).Methods A total of 84 patients who undergoing ERCP admitted in our hospital from December 2017 to December 2019 were selected and randomly divided into phloroglucinol group(given phloroglucinol injection before ERCP)and anisodamine group(given anisodamine injection before ERCP),with 42 cases in each group.The clinical effects of the two groups were compared.Results The operation time and duration of abdominal pain in the phloroglucinol group were shorter than those in the anisodamine group,and the incidence of pancreatitis in the phloroglucinol group was lower than that in the anisodamine group(P<0.05).After treatment,the levels of amylase and CRP in the two groups improved,but those of the phloroglucinol group were lower than the anisodamine group(P<0.05).The incidences of high blood pressure and dysuria in the phloroglucinol group were lower than those in the anisodamine group(P<0.05);there were no significant differences in the incidences of palpitation,nausea and vomiting between the two groups(P>0.05).Conclusion Compared with anisodamine,phloroglucinol in the prevention of pancreatitis after ERCP has a better effect,it can effectively improve the levels of amylase and CRP,with less adverse reactions,which is safe and reliable.

关 键 词：间苯三酚 山莨菪碱 经内镜逆行胰胆管造影术 胰腺炎 

分 类 号：R575.7[医药卫生—消化系统]