2002—2019年上海市浦东新区居民肝癌死亡特征及减寿率分析  

Liver Carcinoma-related Mortality and Potential Years of Life Lost among Residents in Pudong New Area of Shanghai between 2002 and 2019

作　　者：陈亦晨 曲晓滨 孙良红 李小攀 陈涵一 陈华 周弋 肖绍坦 CHEN Yichen;QU Xiaobin;SUN Lianghong;LI Xiaopan;CHEN Hanyi;CHEN Hua;ZHOU Yi;XIAO Shaotan(Shanghai Pudong New Area Center for Disease Control and Prevention/Fudan University Pudong Institute of Preventive Medicine,Shanghai 200136,China)

机构地区：[1]上海市浦东新区疾病预防控制中心复旦大学浦东预防医学研究院,200136

出　　处：《中国全科医学》2021年第12期1517-1522,共6页Chinese General Practice

基　　金：上海市浦东新区卫生系统学科带头人培养计划(PWRd2019-11);浦东新区疾病预防控制中心“新星计划”人才培养项目(PDCDC-XX2020-01);上海市公共卫生体系建设三年行动计划(2020—2022年)优秀青年人才培养计划(GWV-10.2-YQ43)。

摘　　要：背景肝恶性肿瘤是全球常见的消化系统肿瘤之一,浦东新区居民肝恶性肿瘤死亡的流行病学资料依然缺乏。目的了解2002—2019年浦东新区居民肝癌死亡特征与所导致的寿命损失,为制定针对性的干预措施提供依据。方法以浦东新区户籍人口为对象,以户籍居民死因数据库为基础,从中筛选出死亡日期在2002—2019年的肝癌死亡资料进行分析。居民死因资料采用国际疾病分类第10版(ICD-10)进行编码与归类,肝癌的编码范围为C22。分别计算浦东新区居民肝癌粗死亡率、标化死亡率、潜在减寿年数(PYLL)、潜在减寿率(PYLLR)、平均减寿年数(AYLL)、标化潜在减寿年数(SPYLL)以及标化潜在减寿率(SPYLLR),对浦东新区居民肝癌死亡情况以及肝癌导致的寿命损失情况进行分析。肝恶性肿瘤死亡率与寿命损失的变化趋势采用年均变化百分比(APC)进行分析。结果2002—2019年浦东新区居民肝癌死亡12522例,年均粗死亡率为25.38/10万,标化死亡率为12.29/10万。2002—2019年浦东新区居民肝癌粗死亡率、标化死亡率均呈逐年下降趋势(粗死亡率:APC=-1.88%,Z=-12.468,P<0.001;标化死亡率:APC=-4.71%,Z=-10.601,P<0.001)。男性、女性居民肝癌粗死亡率与标化死亡率均呈下降趋势(P<0.001)。2002—2019年15~59岁、60~79岁浦东新区居民肝癌粗死亡率总体呈下降趋势(P<0.001),80岁以上浦东新区居民肝癌死亡率保持稳定(P=0.053)。2002—2019年浦东新区居民肝癌死亡PYLL为98580年,PYLLR为2.00‰,AYLL为7.87年/人,SPYLL为61767年,SPYLLR为1.25‰。2002—2019年浦东新区居民肝癌死亡PYLLR、SPYLLR、AYLL总体均呈逐年下降趋势(P<0.001),除2002—2010年浦东新区居民肝癌死亡AYLL保持稳定(P=0.853)。男性居民肝癌死亡PYLL为81126年,PYLLR为3.29‰,AYLL为9.20年/人,SPYLL为50225年,SPYLLR为2.04‰。女性居民肝癌死亡PYLL为17454年,PYLLR为0.71‰,AYLL为4.72年/人,SPYLL为10942年,SPYLLR为0.44Background Liver carcinoma is a common digestive malignancy worldwide.There is still lack of epidemiological data of liver carcinoma-related deaths of residents in Pudong New Area.Objective To explore liver carcinomarelated mortality and potential years of life lost(PYLL)among residents in Pudong New Area of Shanghai between 2002 and 2019,to provide a reference for the development of targeted interventions.Methods Data of people who died of liver carcinoma(ICD-10 C22)during 2002—2019 were collected from Pudong New Area’Residents Death Surveillance Database with death causes classified by the ICD-10.The crude mortality rate,age-standardized mortality rate,PYLL,rate of PYLL,average PYLL,age-standardized PYLL,and age-standardized PYLL rate were calculated and used to analyze the deaths and PYLL from liver carcinoma.The tendency of mortality and PYLL were estimated by annual percent change(APC).Results During 2002—2019,12522 cases died of liver carcinoma in Pudong New Area,with 25.38/100000 and 12.29/100000 as the average annual crude mortality rate and average annual standardized mortality rate,respectively.Both the crude mortality rate and the agestandardized mortality rate of liver carcinoma declined over the years(APC=-1.88%,Z=-12.468,P<0.001;APC=-4.71%,Z=-10.601,P<0.001).And these two indicators also showed a downward trend either among males or females(P<0.001).The crude mortality of liver carcinoma declined over years for those aged 15-59 and those aged 60-79(P<0.001),but kept stable for those over 80 years old(P=0.053).The PYLL of liver carcinoma was 98580 years,the PYLL rate was 2.00‰,the average PYLL was 7.87 years per person,age-standardized PYLL was 61767 years and age-standardized PYLL rate was 1.25‰,respectively.The PYLL rate,age-standardized PYLL rate and average PYLL due to liver carcinoma on total showed a downward trend during 2002 to 2019(P<0.001).However,the trend of average PYLL kept stable between 2002 and 2010(P=0.853).The PYLL,PYLL rate,average PYLL,age-standardized PYLL,and age-stan

关 键 词：肝肿瘤 死亡率 变化趋势 潜在减寿年数 数据说明 统计 

分 类 号：R735.7[医药卫生—肿瘤]