The genetic framework for development of nephrolithiasis  

作　　者：Vinaya Vasudevan Patrick Samson Arthur D.Smith Zeph Okeke 

机构地区：[1]Smith Institute for Urology,Hofstra Northwell School of Medicine,Lake Success,NY,USA

出　　处：《Asian Journal of Urology》2017年第1期18-26,共9页亚洲泌尿外科杂志（英文）

摘　　要：Over 1%-15% of the population worldwide is affected by nephrolithiasis,which remains the most common and costly disease that urologists manage today.Identification of atrisk individuals remains a theoretical and technological challenge.The search for monogenic causes of stone disease has been largely unfruitful and a technological challenge;however,several candidate genes have been implicated in the development of nephrolithiasis.In this review,we will review current data on the genetic inheritance of stone disease,as well as investigate the evolving role of genetic analysis and counseling in the management of nephrolithiasis.

关 键 词：GENETICS HYPERCALCIURIA NEPHROLITHIASIS UROLITHIASIS Calcium sensing receptor CYSTINURIA Medullary sponge kidney Autosomal dominant polcystic kidney disease Uric acid nephrolithiasis HYPERCALCIURIA 

分 类 号：R73[医药卫生—肿瘤]