纳米炭用于胃癌根治术中淋巴结示踪效果的Meta分析  

Meta-analysis of the tracer effect of lymph node in radical gastrectomy with carbon Nano-Particle

作　　者：熊海波 余松 何雪铼 侯能易[1] 王越 付俊文 张华[1] 许杰 王康[1] 庞明辉[1,2] Xiong Haibo;Yu Song;He Xuelai;Hou Nengyi;Wang Yue;Fu Junwen;Zhang Hua;Xu Jie;Wang Kang;Pang Minghui(Department of Gastrointestinal Surgery,Sichuan Academy of Medical Sciences&Sichuan Province People’s Hospital,Chengdu 610072,China;School of Medicine,University of Electronic Science and Technology,Chengdu 611731,China;The First Department of General Surgery,Zigong No.4 People’s Hospital,Zigong 643000,China)

机构地区：[1]四川省医学科学院·四川省人民医院胃肠外科,成都610072 [2]电子科技大学医学院,成都611731 [3]自贡市第四人民医院普外一科,643000

出　　处：《中华普通外科学文献（电子版）》2021年第1期75-80,共6页Chinese Archives of General Surgery(Electronic Edition)

基　　金：成都市科技局重点研发支撑计划技术创新研发项目(2019-YF05-00647-SN);四川省医学科学院·四川省人民医院临床研究与转化基金项目(2017LY05);四川省卫生厅基金项目(130163)。

摘　　要：目的通过Meta分析评价纳米炭用于胃癌根治术中淋巴结示踪的效果。方法检索Pubmed、Web of Science、Cochrane Library、中国知网、万方和维普数据库,收集建库至2020年5月间发表的国内外有关纳米炭用于胃癌根治术中淋巴结示踪的随机对照试验(RCT),采用RevMan 5.3软件分析评价淋巴结示踪效果。结果最终纳入19项RCT共1402例患者,其中纳米炭组和对照组各701例。纳米炭组淋巴结检出数、微小淋巴结清除率和检出淋巴结转移率均优于对照组,黑染淋巴结明显高于未黑染淋巴结的转移率,差异有统计学意义(Z=8.27、3.54、2.59、4.06,均P<0.05)。两组淋巴结检出数目的漏斗图提示无明显发表偏倚(P=0.07)。结论胃癌根治术中应用纳米炭有助于更加准确清扫淋巴结及微小淋巴结,提高转移淋巴结的检出,从而有助于术后病理分期的判断及预后评估。Objective To evaluate the effect of carbon Nano-Particle on lymph node tracing in radical gastrectomy by Meta-analysis.Methods A study search was undertaken in PubMed,Cochrane Library,FMRS,CNKI,Wanfang and VIP database from the date of their establishment to May 2020.RevMan 5.3 software was used to analyze the effect of node tracing.Results A total of 1402 patients with 19 RCTs were enrolled,including 701 cases in the Nano-Particle group and 701 in the control group.Numbers of harvested lymph nodes,rate of micro lymph nodes,rate of lymph node metastasis in the Nano-Particle group were better than those in the control group,and the metastasis rate of black-dyed lymph nodes was significantly higher than that of non black-dyed lymph nodes in the Nano-Particle group,with statistically significant differences(Z=8.27,3.54,2.59,4.06;all P<0.05).Funnel plot showed no significant publication bias in the number of harvested lymph nodes between the two groups(P=0.07).Conclusion The application of Nano-Particle in radical gastrectomy of gastric cancer is helpful to clean lymph nodes and micro lymph nodes accurately,and improve the detection of metastatic lymph nodes,which is helpful to the judgment of postoperative pathological stage and prognosis evaluation.

关 键 词：胃肿瘤 淋巴结 纳米炭 META分析 

分 类 号：R735.2[医药卫生—肿瘤]