基于胶质瘤术中荧光剂的临床应用与研究进展  

Clinical application and research progress of fluorescein in the operation of glioma

作　　者：陈泽波 吕胜青 范宏军 朱潇鹏 韩德清[1] Chen Zebo;LüShengqing;Fan Hongjun;Zhu Xiaopeng;Han Deqing(Department of Neurosurgery,The Affiliated Zhuzhou Hospital,Xiangya Medical College,Central South University;Department of Neurosurgery,Xinqiao Hospital,Array Medical University)

机构地区：[1]中南大学湘雅医学院附属株洲医院神经外科,株洲412000 [2]陆军军医大学第二附属医院神经外科,重庆400000

出　　处：《重庆医科大学学报》2021年第1期97-100,共4页Journal of Chongqing Medical University

基　　金：湖南省技术创新引导计划资助项目(编号:2018SK52802)。

摘　　要：脑胶质瘤是中枢神经系统最常见的原发性、恶性肿瘤,预后不良,致残率和死亡率高。目前已证实,在安全范围内提高肿瘤的切除程度,有利于延长患者的生存期、改善患者预后。荧光引导技术(fluorescence guided technique,FGT)是利用荧光成像试剂实现术中脑胶质瘤边缘的可视化,从而辅助术者在安全范围内更精准地切除肿瘤。目前运用于临床的荧光成像试剂有荧光素钠(sodium fluorescein,SF)、5-氨基乙酰丙酸(5-aminolevulinic acid,5-ALA)、吲哚菁绿(indocyanine green,ICG)、金丝桃素、他拉泊芬钠(talaporfin sodium,TPS);也有大量的新型荧光试剂在进行积极的临床或临床前实验。本文将对脑胶质瘤的术中荧光成像剂进行综述。Glioma is the most common primary malignant tumor in the central nervous system,with poor prognosis and high morbidity and mortality.It has been confirmed that the maximum excision of tumors within a safe range is beneficial to extend progression-free survival and overall survival,and improve patients’prognosis.Fluorescence guided technique(FGT)can realize the visualization of the edge of brain glioma during operation by using fluorescent imaging reagent,so as to assist the surgeon in more accurate tumor resection within the safe range.At present,the fluorescence imaging reagents used in clinic include sodium fluorescein(SF),5-aminolevulinic acid(5-ALA),indocyanine green(ICG),hypericin,talaporfin sodium(TPS),etc.In addition,a large number of new fluorescent agents are actively used in clinical or preclinical trials.This paper reviewed various intraoperative fluorescence imaging reagents for gliomas.

关 键 词：脑胶质瘤 荧光素钠 5-氨基乙酰丙酸 吲哚菁绿 金丝桃素 他拉泊芬钠 新型荧光试剂 

分 类 号：R739.41[医药卫生—肿瘤]