恶性肿瘤中HOTAIRM1的调控作用及机制  

Regulatory effects and mechanisms of HOTAIRM1 in malignant tumors

作　　者：赵俞乔 苏志雷[1] 崔云甫[1] 关沧海 姜兴明[1] ZHAO Yu-qiao;SU Zhi-lei;CUI Yun-fu;GUAN Cang-hai;JIANG Xing-ming(Department of HPB Surgery,the 2nd Affiliated Hospital of Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院胆胰外科,黑龙江哈尔滨150086

出　　处：《基础医学与临床》2021年第2期262-266,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(81602088)。

摘　　要：HOTAIRM1是一种新近发现的长链非编码RNA(lncRNA),其在多种恶性肿瘤中呈现异常表达,并通过特定的信号传导途径调控mRNA、miRNA以及相应靶基因和靶蛋白,从而在肿瘤细胞的增殖、迁移、侵袭中起到重要作用。同时,HOTAIRM1与临床病理学和分子病理学密切相关,在患者的治疗和预后评估中也显现出巨大的潜力。HOTAIRM1,a newly found long non-coding RNA(lncRNA),is abnormally expressed in diverse malignant tumors,regulated mRNA,miRNA,relevant target gene or protein through specific signal transduction pathways to function in mechanisms of proliferation,invasion and metastasis of tumor cells.HOTAIRM1 is closely related to the clinicopathology or molecular pathology and have shown great potential in therapy and predicting prognosis of patients.

关 键 词：长链非编码RNA HOTAIRM1 肿瘤 调控作用 

分 类 号：R730[医药卫生—肿瘤]