脑血流自动调节研究发展史  

Development history of cerebral autoregulation

作　　者：李凡[1] 邢海英[1] 金海强[1] 孙云闯[1] 彭清[1] 孙葳[1] 王朝霞[1] 黄一宁[1] LI Fan;XING Hai-ying;JIN Hai-qiang;SUN Yun-chuang;PENG Qing;SUN Wei;WANG Zhao-xia;HUANG Yi-ning(Department of Neurology,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院神经内科,100034

出　　处：《中国现代神经疾病杂志》2021年第1期9-13,共5页Chinese Journal of Contemporary Neurology and Neurosurgery

摘　　要：脑血流自动调节系指在全身血压波动的情况下脑血流量保持相对恒定的能力。脑血流自动调节相关研究迄今已有近百年历史,从动物模型到无创性在体实时脑血流动力学监测,检测技术的进步特别是经颅多普勒超声的广泛应用和数学建模方法的引入,为脑血流自动调节研究带来了革新。本文旨在总结脑血流自动调节机制及检测技术的发展史,以为临床开展相关研究提供参考。Cerebral autoregulation(CA)refers to the ability to maintain cerebral blood flow(CBF)relatively constant under the condition of systemic arterial blood pressure(ABP)fluctuation.Up to now,the research on the function of CA has a history of nearly 100 years.From animal models to noninvasive realtime human hemodynamic monitoring,progress of detecting techniques,especially the wide application of transcranial Doppler ultrasonography(TCD)and the introduction of mathematical methods have brought revolutionary changes to the study of CA.This study aims to summarize the development history of mechanism of CA and detecting techniques,and to provide reference for the related clinical study.

关 键 词：卒中 脑缺血 脑血管循环 血流动力学 超声检查 多普勒 经颅 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]