偏头痛与卵圆孔未闭研究进展  

Research progress of migraine and patent foramen ovale

作　　者：刘凯[1] 赵嘉玮 张锐[1] 高远[1] 刘晗 许予明[1] 宋波[1] LIU Kai;ZHAO Jia-wei;ZHANG Rui;GAO Yuan;LIU Han;XU Yu-ming;SONG Bo(Department of Neurology,The First Affiliated Hospital of Zhengzhou University/He'nan Key Laboratory of Cerebrovascular Disease,Zhengzhou 450052,He'nan,China)

机构地区：[1]郑州大学第一附属医院神经内科,河南省脑血管病重点实验室,450052

出　　处：《中国现代神经疾病杂志》2021年第1期53-57,共5页Chinese Journal of Contemporary Neurology and Neurosurgery

摘　　要：偏头痛是临床常见的慢性神经血管性疾病,严重影响患者生活质量。研究显示,卵圆孔未闭可能与偏头痛之间存在一定关联性,如卵圆孔未闭相关右向左分流引起的短暂性低氧血症,或血管活性物质穿过未闭合的卵圆孔,避开肺组织代谢直接进入动脉系统,以及矛盾微栓塞等机制均可能与卵圆孔未闭相关偏头痛有关,尤其是先兆型偏头痛。卵圆孔未闭封堵术可使部分偏头痛患者获益。本文拟对卵圆孔未闭与偏头痛的相关性、发生机制以及预防与治疗进行概述。Migraine is a common clinical chronic neurovascular disease,which seriously affects the quality of life of patients.Studies have shown that patent foramen ovale(PFO)may be related to migraine,such as transient hypoxemia caused by patent foramen ovale related right-to-left shunt,or vasoactive substances passing through an unclosed oval foramen,avoiding lung tissue metabolism and directly entering the arterial system,and contradictory micro-embolism and other mechanisms may be related to migraines related to patent foramen ovale,especially migraine with aura.The closure of patent foramen ovale can benefit some migraine patients.This article intends to outline the relationship between patent foramen ovale and migraine,and its mechanism,prevention and treatment.

关 键 词：偏头痛 卵圆孔 未闭 心脏导管插入术 综述 

分 类 号：R747.2[医药卫生—神经病学与精神病学]