Compliance in patients with dietary hyperoxaluria: A cohort study and systematic review  

作　　者：Derek B.Hennessey Ned Kinnear Gilbert Rice David Curry Siobhan Woolsey Brian Duggan 

机构地区：[1]Department of Urology,Belfast City Hospital,Belfast,United Kingdom [2]Department of Urology,Austin Hospital,Melbourne,Australia [3]Department of Urology,Ulster Hospital,Belfast,United Kingdom

出　　处：《Asian Journal of Urology》2019年第2期200-207,共8页亚洲泌尿外科杂志（英文）

摘　　要：Objective:Hyperoxaluria leads to calcium oxalate crystal formation and subsequent urolithiasis.This study aims to analyse the effect of treatment compliance in hyperoxaluria,firstly by analysis of patients with non-primary hyperoxaluria and secondly via systematic review in patients with any hyperoxaluria.Methods:In a retrospective cohort study,adults with non-primary hyperoxaluria managed with dietary counselling in 2013 were enrolled.Twenty-four-hour(24 h)urine collections initially and at 6 months were obtained.Compliance was assessed by self-reported dietary compliance and 24 h urinary volume>2 L.Patients were followed for 24 months.Primary outcomes were urinary oxalate and calcium 24 h load at 6 months,and urolithiasis-related procedural rates at 24 months.A Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)-compatible systematic review of compliance among hyperoxaluric patients was performed.Results:In the cohort study,of 19 eligible patients(4 female)with median age 52 years,10(53%)were considered compliant.Compared with the non-compliant group,these patients had significantly increased subsequent 24 h urinary volume(2250 mL vs.1600 mL;p=0.008)and lower procedural rates(10%vs.56%;p=0.033).Subsequent 24 h urinary oxalate load was nonsignificantly lower in compliant patients.Systematic review regarding compliance in hyperoxaluric patients revealed five studies.Only one utilised dietary counselling or analysed compliant vs.non-compliant patients,finding no difference.None examined the effect of compliance on procedural rates.

关 键 词：HYPEROXALURIA UROLITHIASIS Recurrent stone former Metabolic stone disease 

分 类 号：R73[医药卫生—肿瘤]