术前纤维蛋白原/白蛋白比值、全身炎症反应指数对宫颈癌患者预后评估价值研究  

The value of preoperative albumin to fibrinogen ratio and systemic inflammation response index in evaluating the prognosis of patients with cervical cancer

作　　者：赵秀梅[1] 金玲[1] 常春玲[1] 魏海波[1] ZHAO Xiu-mei;JIN Ling;CHANG Chun-ling;WEI Hai-bo(Department of Gynaecology and Obstetrics,Tieling Central Hospital,Tieling 112000,China)

机构地区：[1]铁岭市中心医院妇产科,辽宁铁岭112000

出　　处：《创伤与急危重病医学》2021年第1期21-24,共4页Trauma and Critical Care Medicine

基　　金：辽宁省科学技术计划项目(2017020301)。

摘　　要：目的探讨术前纤维蛋白原/白蛋白比值(FAR)、全身炎症反应指数(SIRI)对宫颈癌患者预后的评估价值。方法选取自2014年1月至2017年1月铁岭市中心医院收治的行手术治疗的124例宫颈癌患者为研究对象。根据患者预后情况分为预后良好组(n=83)与预后不良组(n=41),比较两组患者的临床资料。采用多因素Logistic回归分析影响宫颈癌患者不良预后的危险因素。采用受试者工作特征(ROC)曲线分析FAR、SIRI对宫颈癌患者不良预后的评估价值。结果两组患者在淋巴结转移、组织病理分化、临床分期、脉管浸润、FAR及SIRI等临床资料比较,差异有统计学意义(P<0.05)。ROC曲线结果显示,FAR预测宫颈癌患者不良预后的曲线下面积(AUC)为0.858(95%可信区间0.784~0.932,P=0),敏感度和特异度分别为0.776和0.788;SIRI预测患者不良预后的AUC为0.839(95%可信区间0.761~0.917,P=0),敏感度和特异度分别为0.791和0.754;联合检测预测患者不良预后的AUC为0.914(95%可信区间0.858~0.971,P=0),敏感度和特异度分别为0.821和0.879。多因素Logistic回归分析结果显示,淋巴结有转移、组织病理分化、临床分期、FAR和SIRI是影响宫颈癌患者预后不良的独立危险因素(P<0.05)。结论FAR和SIRI升高是宫颈癌患者预后不良的重要危险因素,术前FAR、SIRI升高对宫颈癌患者预后有一定评估价值。Objective To evaluate the prognostic value of preoperative albumin to fibrinogen ratio(FAR)and systemic inflammatory response index(SIRI)in patients with cervical cancer.Methods A retrospective study was performed on 124 patients with cervical cancer who underwent surgical treatment who were admitted from January 2014 to January 2017.According to the prognosis of patients,they were divided into the good prognosis group(n=83)and the poor prognosis group(n=41).Clinical data of the two groups were compared.Multivariate Logistic regression was used to analyze the risk factors affecting the poor prognosis of cervical cancer patients.receiver operating characteristic(ROC)curve was used to analyze the value of FAR and SIRI in the evaluation of adverse prognosis in patients with cervical cancer.Results The differences in lymph node metastasis,histomathological differentiation,clinical stage,vascular infiltration,FAR and SIRI between the two groups were statistically significant(P<0.05).ROC curve results showed that the area under the curve(AUC)of FAR for predicting adverse prognosis in patients with cervical cancer was 0.858(95%CI:0.784-0.932,P=0),sensitivity and specificity were 0.776 and 0.788,respectively.SIRI predicted poor outcomes with an AUC of 0.839(95%CI:0.761-0.917,P=0),sensitivity and specificity of 0.791 and 0.754,respectively.The AUC of the combined test for predicting poor prognosis was 0.914(95%CI:0.858-0.971,P=0),and the sensitivity and specificity were 0.821 and 0.879,respectively.Multivariate Logistic regression analysis showed that lymph node metastasis,histomathological differentiation,clinical stage,FAR and SIRI were independent risk factors for poor prognosis in patients with cervical cancer(P<0.05).Conclusion The elevation of FAR and SIRI is an important risk factor for poor prognosis in patients with cervical cancer,and the elevation of FAR and SIRI before surgery has a certain evaluation value for the prognosis of patients with cervical cancer.

关 键 词：纤维蛋白原/白蛋白比值 全身炎症反应指数 宫颈癌 预后 

分 类 号：R737.3[医药卫生—肿瘤]