TAC方案新辅助化疗对局部晚期乳腺癌患者的临床疗效及预后的影响  

Effect of TAC Regimen Neoadjuvant Chemotherapy on the Clinical Efficacy and Prognosis of Patients with Locally Advanced Breast Cancer

作　　者：王超 WANG Chao(Jianping Hospital of Traditional Chinese Medicine,Jianping 122400,China)

机构地区：[1]辽宁省建平县中医院,辽宁建平122400

出　　处：《中国医药指南》2021年第2期86-87,共2页Guide of China Medicine

摘　　要：目的分析局部晚期乳腺癌患者应用TAC方案新辅助化疗的临床疗效以及对其预后产生的影响。方法将56例局部晚期乳腺癌患者分成研究组(n=28)与参照组(n=28),分别予以TAC方案及TC方案。对比研究组与参照组病情控制效果、肿瘤病灶远处转移情况、局部复发率以及化疗后不良反应情况。结果研究组临床用药效果优于参照组(P <0.05)。两组患者远处转移率、局部复发率、化疗后不良反应发生率差异均无统计学意义(P> 0.05)。研究组患者中性粒细胞减少以及血小板减少发生率均低于参照组患者(P <0.05)。结论局部晚期乳腺癌患者应用TAC方案新辅助化疗方案可显著提高其病情控制效果。Objective To analyze the clinical efficacy of neoadjuvant chemotherapy with TAC regimen in patients with locally advanced breast cancer and the impact on its prognosis. Methods Fifty-six patients with locally advanced breast cancer were divided into study group(n=28) and reference group(n=28), and each group was given TAC and TC programs. The effect of disease control, distant metastasis of tumor lesions, local recurrence rate and adverse reactions after chemotherapy were compared between the study group and the reference group. Results The clinical medication effect of the study group was better than that of the reference group(P <0.05). There were no statistically significant differences in the rates of distant metastasis, local recurrence, and adverse reactions after chemotherapy between the two groups(P >0.05). The incidence of neutropenia and thrombocytopenia in the study group were lower than those in the reference group(P <0.05). Conclusion The application of TAC neoadjuvant chemotherapy to patients with locally advanced breast cancer can significantly improve their disease control effect.

关 键 词：TAC方案 辅助化疗 局部晚期乳腺癌 远处转移 局部复发 不良反应 

分 类 号：R737.9[医药卫生—肿瘤]