非小细胞肺癌组织中CA199、CA153、CYFRA21-1的表达及其与临床病理特征的相关性  

The exprssion of CA199,CA153 and CYFRA21-1 in non-small cell lung cancer tissues and its correlation with clinicopathological features

作　　者：扈成伟 郭九玲[2] 李冬霞[2] 杨晓慧[3] 郑红霞 HU Chengwei;GUO Jiuling;LI Dongxia;YANG Xiaohui;ZHENG Hongxia(Department of Clinical Laboratory,the No.5 People's Hospital of Hengshui,Hebei Hengshui 053000,China;Department of Clinical Laboratory,the No.2 People's Hospital of Hengshui,Hebei Hengshui 053000,China;Department of Oncology,the No.2 People's Hospital of Hengshui,Hebei Hengshui 053000,China)

机构地区：[1]衡水市第五人民医院检验科,河北衡水0530002 [2]衡水市第二人民医院检验科,河北衡水053000 [3]衡水市第二人民医院肿瘤科,河北衡水053000

出　　处：《现代肿瘤医学》2021年第3期418-422,共5页Journal of Modern Oncology

基　　金：衡水市科技厅项目(编号:2017014017Z)。

摘　　要：目的:探究非小细胞肺癌组织中糖类抗原199(CA199)、糖类抗原153(CA153)、细胞角蛋白19片段抗原(CYFRA21-1)的表达及其与临床病理特征的相关性。方法:选取2016年1月至2017年6月于衡水市第二人民医院接受手术治疗的非小细胞肺癌患者50例,选取所有患者癌组织以及距离癌组织5 cm以上的癌旁组织制作标本待用,对待测标本进行免疫组化染色。采用化学发光法检测患者CA199、CA153、CYFRA21-1表达。结果:癌组织中CA199、CA153、CYFRA21-1表达显著高于癌旁组织(P<0.05)。肿瘤体积≥5 cm~3患者CA199、CA153、CYFRA21-1表达显著高于肿瘤体积<5 cm~3患者(P<0.05)。侵及浆膜的患者CA199、CA153、CYFRA21-1表达显著高于未及浆膜患者(P<0.05)。病理分期为Ⅲ、Ⅳ期的患者CA199、CA153、CYFRA21-1表达显著高于病理分期为Ⅰ、Ⅱ期的患者(P <0.05)。有淋巴结转移情况的患者CA199、CA153、CYFRA21-1表达显著高于无淋巴结转移的患者(P <0.05)。低分化患者CA199、CA153、CYFRA21-1表达高于中分化患者,中分化患者CA199、CA153、CYFRA21-1表达高于高分化患者(P <0.05)。结论:非小细胞肺癌组织中CA199、CA153、CYFRA21-1呈现异常高表达,且与肿瘤体积、浸润程度、病理分期、淋巴结转移情况以及分化程度等临床病理参数具有一定相关性,与非小细胞肺癌发生和演进过程密切相关。Objective:To investigate the expression of carbohydrate antigen 199(CA199),carbohydrate antigen 153(CA153)and cytokeratin 19 fragment antigen(CYFRA21-1)in non-small cell lung cancer tissues and its correlation with clinicopathological features.Methods:We selected 50 patients who received surgical treatment in No.2 People's Hospital of Hengshui from January 2016 to June 2017,and made specimens from all the patients'cancer tissues and the para-cancerous tissues which were more than 5 cm away from the cancer tissues.The specimens were stained by immunohistochemistry.The expression of CA199,CA153 and CYFRA21-1 was detected by chemiluminescence method.Results:The expression of CA199,CA153 and CYFRA21-1 in cancer tissues were significantly higher than those in para-cancerous tissues(P<0.05).The expressions of CA199,CA153 and CYFRA21-1 in patients with tumor volume(≥5 cm 3)were significantly higher than those in patients with tumor volume(<5 cm 3)(P<0.05).The expression of CA199,CA153 and CYFRA21-1 in serous invasion patients were significantly higher than those in missed serous invasion patients(P<0.05).The expression of CA199,CA153 and CYFRA21-1 in patients with pathological stageⅢandⅣwere significantly higher than those in patients with pathological stageⅠandⅡ(P<0.05).The expression of CA199,CA153 and CYFRA21-1 in patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis(P<0.05).The expression of CA199,CA153 and CYFRA21-1 in poorly differentiated patients were higher than those in moderately differentiated patients,and the expression of CA199,CA153 and CYFRA21-1 in moderately differentiated patients were higher than those in well differentiated patients(P<0.05).Conclusion:CA199,CA153 and CYFRA21-1 were highly expressed in non-small cell lung cancer tissues,and they were correlated with clinicopathological parameters such as tumor volume,invasion degree,pathological stage,lymph node metastasis and differentiation degree,and were closely related to the

关 键 词：非小细胞肺癌 糖类抗原199 糖类抗原153 细胞角蛋白19片段抗原 

分 类 号：R734.2[医药卫生—肿瘤]