左、右半结肠癌组织中EphB2的表达及其与预后相关性分析  

The expression of EphB2 in left-side and right-side colon cancer tissues and its correlation with prognosis

作　　者：胡永伟[1] 沈晓军[1] 韩玮[1] 曹方[1] 丁厚中[1] 陈在昌[1] 陆伟杰[1] HU Yongwei;SHEN Xiaojun;HAN Wei;CAO Fang;DING Houzhong;CHEN Zaichang;LU Weijie(Department of General Surgery,Kunshan Hospital Affiliated to Jiangsu University,Jiangsu Kunshan 215300,China)

机构地区：[1]江苏大学附属昆山医院普外科,江苏昆山215300

出　　处：《现代肿瘤医学》2021年第3期451-454,共4页Journal of Modern Oncology

基　　金：昆山市社会发展科技计划项目(编号:KS1654);江苏大学医学临床科技发展基金项目(编号:JLY20160041)。

摘　　要：目的:探讨人结肠癌组织中EphB2蛋白的表达情况,对比分析左、右半结肠癌组织中EphB2蛋白的表达并分析其与预后相关性。方法:选取180例结肠癌标本,应用免疫组化检测结肠癌组织及癌旁组织中EphB2蛋白的表达,并对病理参数及预后情况进行分析。结果:左半结肠癌组织中,EphB2与组织学分级、淋巴结转移及Dukes分期呈负相关;右半结肠癌组织中,EphB2表达与组织学分级、淋巴结转移等均无关。左半结肠癌患者5年生存率明显高于右半结肠癌患者;右半结肠癌患者EphB2表达水平与总体生存之间无关;而左半结肠癌患者低水平EphB2预示着预后不佳。结论:左、右半结肠癌组织中,EphB2表达与组织学分级、淋巴结转移及Dukes分期呈负相关,且左半结肠癌患者低水平EphB2预示着预后不佳。Objective:To investigate the expression of EphB2 protein in human colon cancer tissues,we compared the expression of EphB2 protein between left colon cancer(LCC)and right colon cancer(RCC)tissues and analyzed its prognostic value.Methods:180 cases of colon cancer specimens were selected for radical resection in Kunshan Hospital Affiliated to Jiangsu University.Immunohistochemistry was used to detect the expression of EphB2 protein in colon cancer tissues and para-carcinoma tissues,and the pathological parameters and prognosis were analyzed.Results:In the LCC tissues,EphB2 was negatively correlated with histological grade,lymph node metastasis and Dukes stage.EphB2 protein expression was not related to age,gender,histological type,tumor size,histological grade,lymph node metastasis and Dukes stage in RCC tissues.The 5-year survival rate of LCC was significantly higher than that of RCC.Although EphB2 expression was not related to 5-year overall survival(OS)in all patients or patients with RCC.Low level of EphB2 in the LCC patients predicted poor prognosis.Conclusion:In the LCC and RCC tissues,EphB2 was negatively correlated with histological grade,lymph node metastasis and Dukes stage.Low level of EphB2 in the LCC patients predicted poor prognosis.

关 键 词：EPHB2 结肠癌 预后 

分 类 号：R735.35[医药卫生—肿瘤]